Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Nat Prod Res. 2022 Mar;36(5):1236-1244. doi: 10.1080/14786419.2020.1869971. Epub 2021 Jan 4.
A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS, IR and CD data. Chalcone exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC values of 1.74 ± 0.91 and 1.95 ± 0.95 µg/mL, respectively. Chalcones , , and as well as flavones , and showed moderate cytotoxicity with IC values ranging from 5.39 to 14.00 µg/mL.[Formula: see text].
从 Kurz 的根部分离得到了一种新的黄烷酮和一种新的查尔酮，即布兰迪索酮 F 和 G，此外还发现了十六种已知的化合物。所有分离化合物的化学结构均通过光谱方法鉴定，包括 1D-NMR、2D-NMR、MS、IR 和 CD 数据。查尔酮对肝癌 HepG2 和胆管癌 KKU-M156 细胞系表现出最强的细胞毒性，IC 值分别为 1.74 ± 0.91 和 1.95 ± 0.95 μg/mL。查尔酮 、 、 以及黄酮 、 表现出中等的细胞毒性，IC 值范围为 5.39 至 14.00 μg/mL。
