School of Life Sciences, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK.
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle on Tyne, UK.
Int J Food Sci Nutr. 2021 Sep;72(6):805-815. doi: 10.1080/09637486.2020.1868411. Epub 2021 Jan 4.
This study evaluated the association of urinary nitrate concentrations with cognition in older subjects enrolled in the NHANES study. We also explored whether associations between urinary nitrate and cognition were modified by cardiovascular risk, vitamin D status and vitamin C intake. Two NHANES cycles were merged (2011-2012 and 2013-2014) and a total of 1,015 adults aged 60-80 (69.4 ± 0.3) years were included. Cognition was assessed using the Word List Learning, Word List Recall, Animal Fluency and the Digit Symbol Substitution tests. Urinary nitrate was analysed using electrospray tandem mass spectrometry. Urinary nitrate concentrations were not associated with cognitive performance on any of the cognitive tests. Associations were also not significant in subjects at greater risk for cognitive impairment (i.e. high cardiovascular risk and non-optimal vitamin D status). Longitudinal analyses are needed to explore the associations of urinary nitrate concentrations with dietary nitrate intake and cognitive function.
这项研究评估了 NHANES 研究中纳入的老年受试者的尿硝酸盐浓度与认知之间的关联。我们还探讨了尿硝酸盐与认知之间的关联是否受到心血管风险、维生素 D 状况和维生素 C 摄入量的影响。合并了两个 NHANES 周期（2011-2012 年和 2013-2014 年），共纳入了 1015 名年龄在 60-80 岁的成年人（69.4±0.3）岁。使用单词列表学习、单词列表回忆、动物流畅性和数字符号替代测试评估认知能力。使用电喷雾串联质谱法分析尿硝酸盐。尿硝酸盐浓度与任何认知测试的认知表现均无相关性。在认知障碍风险较高的受试者（即心血管风险高和维生素 D 状态不理想）中，相关性也不显著。需要进行纵向分析来探讨尿硝酸盐浓度与饮食硝酸盐摄入和认知功能之间的关联。
