Kim Hyesook, Kim Ggotpin, Jang Won, Kim Seong Yoon, Chang Namsoo
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
Nutr J. 2014 Dec 17;13(1):118. doi: 10.1186/1475-2891-13-118.
It is possible that blood B vitamins level and cognitive function may be affected by dietary intake of these vitamins, no study however has yet been conducted on relationships between B vitamins intake and cognitive function among elderly population in Korea. This study examined the relationship between B vitamins intake and cognitive function among elderly in South Korea.
Participants consisted of 100 adults with mild cognitive impairment (MCI), 100 with Alzheimer's disease (AD), and 121 normal subjects. Dietary intake data that included the use of dietary supplements were obtained using a 24-hour recall method by well-trained interviewers. Plasma folate and vitamin B12 concentrations were analyzed by radioimmunoassay, and homocysteine (Hcy) was assessed by a high performance liquid chromatography-fluorescence method.
Plasma levels of folate and vitamin B12 were positively correlated with B vitamins intake; and plasma Hcy was negatively correlated with total intake of vitamin B2, vitamin B6, vitamin B12 and folate. In the AD group, a multiple regression analysis after adjusting for covariates revealed positive relationships between vitamin B2 intake and test scores for the MMSE-KC, Boston Naming, Word Fluency, Word List Memory and Constructional Recall Tests; and between vitamin B6 intake and the MMSE-KC, Boston Naming, Word Fluency, Word List Memory, Word List Recognition, Constructional Recall and Constructional Praxis Tests. Positive associations were observed between vitamin B12 intake and the MMSE-KC, Boston Naming, Constructional Recall and Constructional Praxis Tests, and between folate intake and the Constructional Recall Test. In the MCI group, vitamin B2 intake was positively associated with the MMSE-KC and Boston Naming Test, vitamin B6 intake was positively associated with the Boston Naming Test, and folate intake was positively associated with the MMSE-KC and Word List Memory test. No associations were observed in the normal group.
These results suggested that total B vitamins intake is associated with cognitive function in cognitively impaired AD and MCI elderly, and the association is stronger in AD patients.
血液中B族维生素水平和认知功能可能会受到这些维生素膳食摄入量的影响，然而韩国尚未开展关于老年人B族维生素摄入量与认知功能之间关系的研究。本研究调查了韩国老年人B族维生素摄入量与认知功能之间的关系。
参与者包括100名轻度认知障碍（MCI）成年人、100名阿尔茨海默病（AD）患者和121名正常受试者。由训练有素的访谈员采用24小时回忆法获取包括膳食补充剂使用情况在内的膳食摄入数据。采用放射免疫分析法分析血浆叶酸和维生素B12浓度，采用高效液相色谱-荧光法评估同型半胱氨酸（Hcy）。
血浆叶酸和维生素B12水平与B族维生素摄入量呈正相关；血浆Hcy与维生素B2、维生素B6、维生素B12和叶酸的总摄入量呈负相关。在AD组中，调整协变量后的多元回归分析显示，维生素B2摄入量与简易精神状态检查表-韩国版（MMSE-KC）、波士顿命名、词语流畅性、词语列表记忆和结构回忆测试的得分呈正相关；维生素B6摄入量与MMSE-KC、波士顿命名、词语流畅性、词语列表记忆、词语列表识别、结构回忆和结构操作测试呈正相关。维生素B12摄入量与MMSE-KC、波士顿命名、结构回忆和结构操作测试呈正相关，叶酸摄入量与结构回忆测试呈正相关。在MCI组中，维生素B2摄入量与MMSE-KC和波士顿命名测试呈正相关，维生素B6摄入量与波士顿命名测试呈正相关，叶酸摄入量与MMSE-KC和词语列表记忆测试呈正相关。在正常组中未观察到相关性。
这些结果表明，B族维生素总摄入量与认知功能受损的AD和MCI老年人的认知功能相关，且这种关联在AD患者中更强。
