Dr Khaleda Akter, Specialist, Laboratory Diagnostic Services, Ibrahim Cardiac Hospital & Research Institute (ICH&RI), Dhaka, Bangladesh; E-mail:
Mymensingh Med J. 2021 Jan;30(1):176-181.
Incidence of Myocardial Infarction is increasing day by day in developing countries. Most of the patients who sustain myocardial infarction have coronary atherosclerosis. There are several risk factors for the development of atherosclerosis. Among all the risk factors, vitamin D deficiency has been proposed to play an important role in the development of atherosclerosis. With this aim, a case-control study was carried out to explore the association of serum vitamin D with acute myocardial infarction. The enrolled study subjects were categorized into Group A which comprised of STEMI, Group B, comprised of NSTEMI and Group C comprised of age and sex matched individuals free from acute myocardial infarction. The mean values of serum vitamin D (in ng/ml) were 20.17, 20.8 and 24.77 respectively in STEMI, NSTEMI and control groups. It differed significantly among groups (p<0.001) and it was significantly low in STEMI and NSTEMI groups compared to control group (p<0.001 and p=0.004). From this study it can be concluded that low serum vitamin D is an independent risk factor for developing acute myocardial infarction. Individuals with serum vitamin D <20ng/ml have higher chance of developing acute myocardial infarction compared to those with serum vitamin D >20ng/ml.
在发展中国家，心肌梗死的发病率日益增高。大多数发生心肌梗死的患者都有冠状动脉粥样硬化。有许多危险因素可导致动脉粥样硬化的发生。在所有的危险因素中，维生素 D 缺乏被认为在动脉粥样硬化的发生中起着重要作用。为此，进行了一项病例对照研究，以探讨血清维生素 D 与急性心肌梗死的关系。纳入的研究对象分为 A 组（包括 STEMI）、B 组（包括 NSTEMI）和 C 组（年龄和性别匹配且无急性心肌梗死的个体）。STEMI、NSTEMI 和对照组中血清维生素 D（ng/ml）的平均值分别为 20.17、20.8 和 24.77。组间差异有统计学意义（p<0.001），且 STEMI 和 NSTEMI 组明显低于对照组（p<0.001 和 p=0.004）。本研究表明，低血清维生素 D 是发生急性心肌梗死的独立危险因素。血清维生素 D<20ng/ml 的个体发生急性心肌梗死的几率高于血清维生素 D>20ng/ml 的个体。
