长非编码 RNA FTX 预测人类癌症预后不良：一项荟萃分析。
Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis.
机构信息
Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, P. R. China.
Department of Gastroenterology, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, P. R. China.
出版信息
Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203995.
BACKGROUND
Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in patients with cancer with conflicting results. This meta-analysis synthesized existing data to clarify the association between FTX with cancer prognosis.
METHODS
PubMed, Embase, Cochrane library, Web of Science, Chinese CNKI, and the Chinese WanFang databases were used to search for relevant studies. The role of FTX in cancers was evaluated by pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs).
RESULTS
Eleven studies comprising 1210 participants including colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastric cancer (GC), renal cell carcinoma (RCC), osteosarcoma (OSC), and glioma were enrolled in this analysis. The meta-analysis showed that high FTX expression was significantly associated with several clinicopathological characteristics, including lymph node metastasis in patients with CRC, GC, HCC, and RCC, distant metastasis in patients with CRC, GC, HCC, and OSC, larger tumor size in patients with CRC, GC, HCC, RCC, and OSC, and subsequently TNM/clinical stage in patients with CRC, GC, HCC, OSC, and glioma. The pooled results from the survival analysis revealed a significant correlation between high FTX expression and shorter OS in patients with HCC, CRC, GC, OSC, and glioma. Further, FTX overexpression could be an independent predictive marker for shorter OS in patients with CRC, HCC, OSC, and glioma.
CONCLUSIONS
FTX may be a potential oncogene, with high FTX expression being associated with a poorer prognosis in patients with CRC, HCC, OSC, and glioma.
背景
多项研究评估了长链非编码 RNA 五端到 Xist（FTX）表达与癌症患者的临床病理特征和生存结局之间的关系，但结果相互矛盾。本荟萃分析综合了现有数据，以阐明 FTX 与癌症预后的关系。
方法
通过 PubMed、Embase、Cochrane 图书馆、Web of Science、中国知网和万方数据库检索相关研究。采用合并优势比（OR）和风险比（HR）及其 95%置信区间（CI）评估 FTX 在癌症中的作用。
结果
共纳入 11 项研究，包括 1210 名参与者，涵盖结直肠癌（CRC）、肝细胞癌（HCC）、胃癌（GC）、肾细胞癌（RCC）、骨肉瘤（OSC）和胶质瘤。荟萃分析表明，FTX 高表达与几种临床病理特征显著相关，包括 CRC、GC、HCC 和 RCC 患者的淋巴结转移、CRC、GC、HCC 和 OSC 患者的远处转移、CRC、GC、HCC、RCC 和 OSC 患者的肿瘤较大，以及 CRC、GC、HCC、OSC 和胶质瘤患者的 TNM/临床分期。生存分析的汇总结果显示，FTX 高表达与 HCC、CRC、GC、OSC 和胶质瘤患者的总生存期（OS）较短显著相关。此外，FTX 过表达可能是 CRC、HCC、OSC 和胶质瘤患者 OS 较短的独立预测标志物。
结论
FTX 可能是一种潜在的癌基因，FTX 高表达与 CRC、HCC、OSC 和胶质瘤患者的预后较差相关。
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