格拉茨医科大学临床病理会议系列：病例编号173：一名77岁前列腺腺癌伴肝转移及水样腹泻患者。 - Suppr

Clinical-Pathological Conference Series from the Medical University of Graz : Case No 173: A 77-year-old patient with adenocarcinoma of the prostate, liver metastases and watery diarrhea.

作者信息

Fabian Elisabeth, Kump Patrizia, Schiller Dietmar, Brcic Iva, Gruber Christine, Heitz Philipp U, Klöppel Günter, Lipp Rainer W, Moinfar Farid, Schöfl Rainer, Fickert Peter, Krejs Guenter J

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

出版信息

Wien Klin Wochenschr. 2021 May;133(9-10):515-522. doi: 10.1007/s00508-020-01791-x. Epub 2021 Jan 4.

DOI:10.1007/s00508-020-01791-x

PMID:33398457

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8116268/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb26/8116268/d45a598e9576/508_2020_1791_Fig1_HTML.jpg

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Clinical-Pathological Conference Series from the Medical University of Graz : Case No 173: A 77-year-old patient with adenocarcinoma of the prostate, liver metastases and watery diarrhea.格拉茨医科大学临床病理会议系列：病例编号173：一名77岁前列腺腺癌伴肝转移及水样腹泻患者。

Wien Klin Wochenschr. 2021 May;133(9-10):515-522. doi: 10.1007/s00508-020-01791-x. Epub 2021 Jan 4.

VIPoma血管活性肠肽瘤

Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome.韦尔纳-莫里森综合征患者胰腺血管活性肠肽瘤的动态钆增强磁共振成像

Eur Radiol. 2001;11(10):1952-5. doi: 10.1007/s003300000813.

Intractable and dramatic diarrhea in liver transplantation recipient with vasoactive intestinal peptide-producing tumor after split liver transplantation: a case report.活体肝移植术后患有血管活性肠肽分泌肿瘤的肝移植受者出现难治性剧烈腹泻：一例报告

Transplant Proc. 2015 Jan-Feb;47(1):171-3. doi: 10.1016/j.transproceed.2014.07.078. Epub 2015 Jan 14.

[Islet cell adenomatosis associated with therapy watery diarrhea and hypokalemia. (Verner-Morrison Syndrome)].[胰岛细胞腺瘤病伴治疗后水样腹泻和低钾血症。（韦尔纳-莫里森综合征）]

Dtsch Z Verdau Stoffwechselkr. 1972;32(3):229-38.

Vasoactive intestinal polypeptide-, somatostatin-, and calcitonin-producing adrenal pheochromocytoma associated with the watery diarrhea (WDHH) syndrome. First case report with immunohistochemical findings.与水样腹泻（WDHH）综合征相关的产生血管活性肠肽、生长抑素和降钙素的肾上腺嗜铬细胞瘤。首例病例报告及免疫组化结果

Cancer. 1985 Mar 1;55(5):1099-106. doi: 10.1002/1097-0142(19850301)55:5<1099::aid-cncr2820550527>3.0.co;2-3.

[Carcinoma of the pancreas with hypokalemic watery diarrhea (Verner-Morrison syndrome). Presentation of a case and review of literature)].[伴有低钾性水样腹泻的胰腺癌（韦尔纳-莫里森综合征）。病例报告及文献复习]

Pathologica. 1979 Sep-Oct;71(1015):641-56.

Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma.因血管活性肠肽瘤导致的水样腹泻、低钾血症、无胃酸（WDHA）综合征引起的低钾性横纹肌溶解症。

South Med J. 2009 Jul;102(7):761-4. doi: 10.1097/SMJ.0b013e3181a5cead.

[VIPoma of the Pancreas].

Praxis (Bern 1994). 2021 Sep;110(11):637-642. doi: 10.1024/1661-8157/a003714.

Watery diarrhea, hypokalemia and hypochlorhydria in a 60-year-old man: a case report.一名60岁男性出现水样腹泻、低钾血症和胃酸过少：病例报告。

Mt Sinai J Med. 1976 Sep-Oct;43(5):625-8.

本文引用的文献

Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model.一种独特的神经内分泌转化前列腺循环肿瘤细胞衍生外植体模型的遗传特征。

Nat Commun. 2020 Apr 20;11(1):1884. doi: 10.1038/s41467-020-15426-2.

Phase 3 Trial of Lu-Dotatate for Midgut Neuroendocrine Tumors.镥[177Lu]奥曲肽治疗中肠神经内分泌肿瘤的3期试验

N Engl J Med. 2017 Jan 12;376(2):125-135. doi: 10.1056/NEJMoa1607427.

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.去势抵抗性神经内分泌前列腺癌的不同克隆进化

Nat Med. 2016 Mar;22(3):298-305. doi: 10.1038/nm.4045. Epub 2016 Feb 8.

Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study.依维莫司治疗晚期肺或胃肠道无功能性神经内分泌肿瘤（RADIANT-4）：一项随机、安慰剂对照的3期研究。

Lancet. 2016 Mar 5;387(10022):968-977. doi: 10.1016/S0140-6736(15)00817-X. Epub 2015 Dec 17.

Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification.晚期神经内分泌肿瘤患者基于链脲佐菌素的化疗——治疗分层的预测和预后标志物

PLoS One. 2015 Dec 2;10(12):e0143822. doi: 10.1371/journal.pone.0143822. eCollection 2015.

VIPoma with multiple endocrine neoplasia type 1 identified as an atypical gene mutation.伴有1型多发性内分泌肿瘤的血管活性肠肽瘤被鉴定为一种非典型基因突变。

BMJ Case Rep. 2015 Nov 12;2015:bcr2015213016. doi: 10.1136/bcr-2015-213016.

Neuroendocrine differentiation in prostate cancer: a mechanism of radioresistance and treatment failure.前列腺癌中的神经内分泌分化：一种放射抵抗和治疗失败的机制。

Front Oncol. 2015 Apr 14;5:90. doi: 10.3389/fonc.2015.00090. eCollection 2015.

Chromogranin A is a potential prognostic marker in prostate cancer patients treated with enzalutamide.嗜铬粒蛋白A是接受恩杂鲁胺治疗的前列腺癌患者的一种潜在预后标志物。

Prostate. 2014 Dec;74(16):1691-6. doi: 10.1002/pros.22890. Epub 2014 Sep 27.

Lanreotide in metastatic enteropancreatic neuroendocrine tumors.兰瑞肽治疗转移性胃肠胰神经内分泌肿瘤。

N Engl J Med. 2014 Jul 17;371(3):224-33. doi: 10.1056/NEJMoa1316158.

Enzalutamide in metastatic prostate cancer before chemotherapy.恩杂鲁胺治疗化疗前转移性前列腺癌。

N Engl J Med. 2014 Jul 31;371(5):424-33. doi: 10.1056/NEJMoa1405095. Epub 2014 Jun 1.

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Clinical-Pathological Conference Series from the Medical University of Graz : Case No 173: A 77-year-old patient with adenocarcinoma of the prostate, liver metastases and watery diarrhea.

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