Centre for Health Services and Policy Research, School of Population and Public Health, University of British Columbia, 201-2206 East Mall, Vancouver, V6T 1Z3, Canada.
Department of Surgery, University of Calgary, Calgary, AB, Canada.
Surg Endosc. 2021 Dec;35(12):6938-6948. doi: 10.1007/s00464-020-08205-z. Epub 2021 Jan 4.
The Gastrointestinal Quality of Life Index (GQLI) is used to measure domains of health and symptoms among people with gastrointestinal disorders. The objective of this study is to calculate the smallest change in the GQLI that is perceived by patients as meaningful among a sample of English-speaking adult patients undergoing elective laparoscopic cholecystectomy for treatment of symptomatic gallbladder disease.
The study is based on retrospective analyses of a sample of participants completing the GQLI and the EQ-5D(3L) preoperatively and six months postoperatively in Vancouver, Canada. Patients are excluded if they are less than 19 years of age, cannot communicate in English, or reside in a long-term care facility. The MID is calculated for the GQLI's domains using distribution and anchor-based methods.
Among eligible patients, the participation rate was 51%. The estimated MID for the overall GQLI value ranged between 4.32 and 11.44. There were no statistically significant differences in the GQLI's MID values between sexes or age subgroups. There were statistically significant differences in the GQLI's MID values by baseline health status.
This study should provide some comfort that the MID values used in discussing change in health and symptoms with elective cholecystectomy patients are robust to sex. Although the sample size may have been inadequate for age-based analyses, the study found large differences in MID values between age subgroups. Statistically significant differences in MID values based on preoperative health supports reporting MID values separately by baseline value. Further research should explore whether age-based differences in MID values exist using larger samples.
胃肠道生活质量指数（GQLI）用于衡量胃肠道疾病患者的健康和症状领域。本研究的目的是计算出在接受择期腹腔镜胆囊切除术治疗有症状的胆囊疾病的英语为母语的成年患者样本中，患者认为有意义的 GQLI 最小变化。
该研究基于在加拿大温哥华完成 GQLI 和 EQ-5D（3L）术前和术后六个月的患者样本的回顾性分析。如果患者年龄小于 19 岁、无法用英语交流或居住在长期护理机构，则将其排除在外。使用分布和锚定方法计算 GQLI 各领域的 MID。
在合格患者中，参与率为 51%。总体 GQLI 值的估计 MID 范围在 4.32 到 11.44 之间。性别或年龄亚组之间 GQLI 的 MID 值没有统计学差异。基线健康状况的 GQLI 的 MID 值存在统计学差异。
本研究应该为讨论与择期胆囊切除术患者的健康和症状变化相关的 MID 值提供一些安慰，即这些 MID 值在性别方面是稳健的。尽管基于年龄的分析样本量可能不足，但该研究发现 MID 值在年龄亚组之间存在很大差异。基于术前健康的 MID 值的统计学差异支持按基线值分别报告 MID 值。进一步的研究应该使用更大的样本量来探讨 MID 值是否存在基于年龄的差异。
