Wu Meiyu, Ruan Jinghua, Zhong Boxiong
Department of Special Economic Animal Science, College of Animal Science, Zhejiang University, Hangzhou 310029, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2020 Dec 25;36(12):2813-2823. doi: 10.13345/j.cjb.200209.
Human epidermal growth factor (hEGF) is a typical member of the growth factor family that activates epidermal growth factor receptors. It is synthesized and secreted by multiple tissues and organs of the human body, regulating the cell proliferation, differentiation and migration via binding to receptors and activating a series of signaling pathways. In recent years, the research on hEGF has been extended to its role in human physiology and pathology, especially in tissue regeneration and wound healing. This paper reviews the research progress of hEGF, briefly describes its gene and protein structure and characteristics, mechanisms and biological effects, with the emphasis on the roles and influences in the healing of gastrointestinal ulcers, skin wound repair and tumor pathology.
人表皮生长因子（hEGF）是激活表皮生长因子受体的生长因子家族的典型成员。它由人体的多个组织和器官合成与分泌，通过与受体结合并激活一系列信号通路来调节细胞增殖、分化和迁移。近年来，对hEGF的研究已扩展到其在人体生理和病理中的作用，特别是在组织再生和伤口愈合方面。本文综述了hEGF的研究进展，简要描述了其基因和蛋白质结构与特性、作用机制和生物学效应，重点阐述了其在胃溃疡愈合、皮肤伤口修复和肿瘤病理学中的作用及影响。
