Damiani Marialessia, Mercante Giuseppe, Abdellaoui Mohammed, Guerlain Joanne, Moya-Plana Antoine, Casiraghi Odile, Temam Stéphane, Tao Yungan, Gorphe Philippe
Department of Head and Neck Oncology, Gustave Roussy Institute, University Paris-Saclay, Villejuif, France.
Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
Laryngoscope. 2021 Jun;131(6):E1980-E1986. doi: 10.1002/lary.29367. Epub 2021 Jan 5.
OBJECTIVES/HYPOTHESIS: We investigated growth patterns and pathological features in intermediate-size laryngeal carcinoma amenable to supraglottic laryngectomy.
Retrospective cohort study.
We reviewed patients who underwent an open partial horizontal laryngectomy (OPHL) type I. We analyzed pathological data, tumor sizes, overall survival, disease-specific survival, local control, and laryngeal preservation. Results were stratified between three groups: group I comprised patients with endolaryngeal carcinoma, group II comprised patients with anterior epilaryngeal carcinoma who underwent an OPHL type I + base of tongue (BOT), group III comprised patients with lateral epilaryngeal carcinoma who underwent an OPHL type I + pyriform sinus (PIR).
Sixty-eight patients were analyzed. The 5-year rates of overall survival, disease-specific survival, local control, and laryngeal preservation were 68.4%, 83.7%, 91.6%, and 98.3%, respectively. The tumor sizes at pathological examination were similar between the three groups (mean 27 mm, P = .80) and were associated with pathological features, notably pre-epiglottic space (PES) invasion (24.9 mm vs. 32.2 mm, P = .01), occult invaded lymph nodes (22.6 mm vs. 29.9 mm, P = .03), and trends for margins status (26.5 mm vs. 29.3 mm, P = .45). The risks of PES invasion, occult lymph nodes, and positive margins, respectively, predominated in group I (41.7%), group II (56.3%), and group III (23.3%).
In intermediate-size tumors amenable to supraglottic laryngectomy, pathological features are associated with tumor size according to group stratification based on tumor location.
4 Laryngoscope, 131:E1980-E1986, 2021.
目的/假设：我们研究了适合声门上喉切除术的中等大小喉癌的生长模式和病理特征。
回顾性队列研究。
我们回顾了接受I型开放性部分水平喉切除术（OPHL）的患者。我们分析了病理数据、肿瘤大小、总生存率、疾病特异性生存率、局部控制率和喉保留情况。结果分为三组：I组包括喉内癌患者，II组包括接受I型OPHL + 舌根（BOT）手术的喉前癌患者，III组包括接受I型OPHL + 梨状窝（PIR）手术的喉侧癌患者。
对68例患者进行了分析。总生存率、疾病特异性生存率、局部控制率和喉保留率的5年率分别为68.4%、83.7%、91.6%和98.3%。三组病理检查时的肿瘤大小相似（平均27 mm，P = 0.80），且与病理特征相关，尤其是会厌前间隙（PES）侵犯（24.9 mm对32.2 mm，P = 0.01）、隐匿性淋巴结侵犯（22.6 mm对29.9 mm，P = 0.03）以及切缘状态趋势（26.5 mm对29.3 mm，P = 0.45）。PES侵犯、隐匿性淋巴结和切缘阳性的风险分别在I组（41.7%）、II组（56.3%）和III组（23.3%）中占主导。
在适合声门上喉切除术的中等大小肿瘤中，根据基于肿瘤位置的分组分层，病理特征与肿瘤大小相关。
4 《喉镜》，131:E1980 - E1986，2021年。
