[与慢性炎症性脱髓鞘性多发性神经根神经病中对类固醇良好反应相关的变量]
[Variables associated with a good response to steroids in chronic inflammatory demyelinating polyradiculoneuropathy].
作者信息
Fuentealba S Mario, Molina D Ignacio, Vera-Calzaretta Aldo, Pérez-Villalobos Cristhian, Klaassen P Gonzalo, Juica A Sergio, González-Burboa Alexis
机构信息
Servicio de Neurología, Hospital Clínico Regional de Concepción "Dr. Guillermo Grant Benavente", Concepción, Chile.
Departamento de Salud Pública, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.
出版信息
Rev Med Chil. 2020 May;148(5):594-601. doi: 10.4067/S0034-98872020000500594.
BACKGROUND
The treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is based on corticosteroids, immunoglobulin and plasmapheresis. In our Health System, corticosteroids are commonly used as first line therapy for economic reasons and accessibility. However, the factors associated with a good response are not well known.
AIM
To assess the association of demographic, clinical and laboratory variables with a favorable response to corticosteroid therapy in patients with CIDP.
MATERIAL AND METHODS
Observational, descriptive, longitudinal and retrospective study of 33 patients with a diagnosis of typical, definitive or probable CIDP, treated with corticosteroids for at least six months.
RESULTS
Twenty-three patients had a good clinical response to corticosteroid treatment and 10 were non-responders. The variables significantly associated with a good response to steroids were a disease lasting less than 1 year prior to the start of treatment, the absence of axonal damage in electromyography a relapsing-recurrent course and a favorable response within two months of treatment.
CONCLUSIONS
Most of these patients with CIDP had good response to corticosteroid therapy.
背景
慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）的治疗基于皮质类固醇、免疫球蛋白和血浆置换。在我们的医疗体系中，出于经济原因和可及性考虑，皮质类固醇通常被用作一线治疗药物。然而，与良好反应相关的因素尚不明确。
目的
评估CIDP患者的人口统计学、临床和实验室变量与皮质类固醇治疗良好反应之间的关联。
材料与方法
对33例诊断为典型、确诊或可能的CIDP患者进行观察性、描述性、纵向和回顾性研究，这些患者接受皮质类固醇治疗至少6个月。
结果
23例患者对皮质类固醇治疗有良好的临床反应，10例无反应。与类固醇治疗良好反应显著相关的变量包括治疗开始前病程少于1年、肌电图检查无轴索损伤、复发-缓解病程以及治疗两个月内有良好反应。
结论
大多数这些CIDP患者对皮质类固醇治疗有良好反应。
Zotero 插件