Gulati A K, Rivner M H, Shamsnia M, Swift T R, Sohal G S
Department of Anatomy, Medical College of Georgia, Augusta 30912.
Muscle Nerve. 1988 Jan;11(1):33-8. doi: 10.1002/mus.880110107.
We studied the fate of skeletal muscle obtained from patients with amyotrophic lateral sclerosis (ALS) after transplantation into immunodeficient nude mice. The transplanted muscle consistently survived in the nude mice without immunological rejection. The myofibers in these muscles underwent degeneration, followed by regeneration, maturation, and eventual functional innervation by the mouse motor neurons. The ability to grow diseased human muscle successfully over a prolonged period in nude mice offers an in vivo model to study the etiology of ALS and possibly of other neuromuscular disorders.
我们研究了将肌萎缩侧索硬化症（ALS）患者的骨骼肌移植到免疫缺陷裸鼠体内后的转归情况。移植的肌肉在裸鼠体内持续存活，未发生免疫排斥反应。这些肌肉中的肌纤维经历了变性，随后再生、成熟，并最终由小鼠运动神经元实现功能性神经支配。在裸鼠体内长时间成功培养患病人类肌肉的能力，为研究ALS以及可能的其他神经肌肉疾病的病因提供了一个体内模型。
