Capodiferro Saverio, Limongelli Luisa, D'Agostino Silvia, Tempesta Angela, Dolci Marco, Maiorano Eugenio, Favia Gianfranco
Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70121 Bari, Italy.
Department of Medical, Oral and Biotechnological Sciences, University of Chieti Pescara, 66100 Chieti, Italy.
Healthcare (Basel). 2021 Jan 1;9(1):33. doi: 10.3390/healthcare9010033.
Juvenile nasopharyngeal angiofibroma is a rare vascular neoplasm, mostly occurring in adolescent males, and representing 0.05% of all head and neck tumors. Nevertheless, it is usually recognized as the most common benign mesenchymal neoplasm of the nasopharynx. Usually, it originates from the posterolateral wall of the nasopharynx and, although histologically benign, classically shows a locally aggressive behavior with bone destruction as well as spreading through natural foramina and/or fissures to the nasopharynx, nasal and paranasal cavities, spheno-palatine foramen, infratemporal fossa and, very rarely, to the cranial cavity. Extranasopharyngeal angiofibroma is considered a distinct entity due to older age at presentation, different localizations (outside the nasopharyngeal pterygopalatine fossa) and attenuated clinical course. Extranasopharyngeal angiofibroma has been sporadically described in the oral cavity. We report a case of extranasopharyngeal angiofibroma with primary and exclusive involvement of the adherent gingiva of the anterior maxilla, managed by preoperative diode laser trans-mucosal photocoagulation and subsequent surgical removal. The current literature on primary extranasopharyngeal angiofibroma is also reviewed.
青少年鼻咽血管纤维瘤是一种罕见的血管性肿瘤，主要发生于青春期男性，占所有头颈部肿瘤的0.05%。然而，它通常被认为是鼻咽部最常见的良性间叶性肿瘤。通常，它起源于鼻咽部的后外侧壁，虽然组织学上为良性，但典型地表现出局部侵袭性行为，伴有骨质破坏，并通过自然孔道和/或裂隙蔓延至鼻咽部、鼻腔和鼻窦、蝶腭孔、颞下窝，极少数情况下可蔓延至颅腔。鼻咽外血管纤维瘤由于发病年龄较大、定位不同（在鼻咽翼腭窝外）以及临床病程较轻，被认为是一种独特的实体。鼻咽外血管纤维瘤在口腔中已有零星报道。我们报告一例鼻咽外血管纤维瘤，主要且仅累及上颌前部附着牙龈，通过术前二极管激光经黏膜光凝及随后的手术切除进行治疗。同时还对原发性鼻咽外血管纤维瘤的现有文献进行了综述。
