Tapper Marlene, McGrowder Donovan A, Dilworth Lowell, Soyibo Adedamola
Department of Pathology, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica.
Department of Medicine, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica.
Diseases. 2021 Jan 3;9(1):5. doi: 10.3390/diseases9010005.
The progression of chronic kidney disease (CKD) is concomitant with complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. The aim of this study is to determine serum cystatin C levels, and the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients.
A cross-sectional study was conducted involving 140 CKD patients (stages 1-5) that were referred to a renal clinic. Demographic data was collected and thyroid function tests, serum 25-OH-vitamin D, cystatin C levels, and routine biochemistry tests were determined using cobas 6000 analyzer.
129 (92.1%) of CKD patients had elevated serum cystatin C levels and there was a stepwise increase from stage 1-5. Overt hypothyroidism was present in one patient and nine had subclinical hypothyroidism. There was a stepwise reduction in serum 25-OH-vitamin D levels from stage 2-5, 31 (22.1%) had vitamin D insufficiency and 31 (22.1%) presented with deficiency.
25-OH-vitamin D deficiency and thyroid disorders are exhibited in chronic kidney disease patients and the severity of the former rises with disease progression, as indicated by elevated cystatin C levels. Routine screening and timely intervention is recommended so as to reduce the risk of cardiovascular diseases.
慢性肾脏病（CKD）的进展伴随着多种并发症，包括甲状腺功能障碍、血脂异常和心血管疾病。本研究旨在测定CKD患者的血清胱抑素C水平，以及维生素D缺乏和甲状腺功能障碍的患病率。
对转诊至肾脏科门诊的140例CKD患者（1-5期）进行横断面研究。收集人口统计学数据，并使用cobas 6000分析仪测定甲状腺功能、血清25-羟维生素D、胱抑素C水平及常规生化指标。
129例（92.1%）CKD患者血清胱抑素C水平升高，且从1期到5期呈逐步上升趋势。1例患者出现明显甲状腺功能减退，9例为亚临床甲状腺功能减退。血清25-羟维生素D水平从2期到5期逐步降低，31例（22.1%）存在维生素D不足，31例（22.1%）存在维生素D缺乏。
CKD患者存在25-羟维生素D缺乏和甲状腺疾病，且前者的严重程度随疾病进展而增加，表现为胱抑素C水平升高。建议进行常规筛查并及时干预，以降低心血管疾病风险。
