Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, 68782Tanta University, Tanta, Egypt.
Hum Exp Toxicol. 2021 Jul;40(7):1053-1063. doi: 10.1177/0960327120983873. Epub 2021 Jan 5.
Clozapine is a frequently prescribed atypical antipsychotic drug. Various case reports documented the successful recovery of acute antipsychotics toxicity in association with the administration of intralipid emulsion (ILE).
This study aimed to assess the adjuvant therapeutic role of SMOF Lipid administration on the outcomes of acute clozapine poisoning.
Forty patients with acute clozapine poisoning were randomly allocated into two equal groups. The control group received the standard supportive treatment only, whereas the intervention group received the standard supportive treatment plus SMOF Lipid 20% infusion. All patients were subjected to history taking, full clinical examination, and laboratory investigations. The study outcomes were evaluated.
The mean Glasgow Coma Scale (GCS) at 6 hours (13.1 ± 2.3 vs 9.2 ± 2, p < 0.001) and 12 hours (14.3 ± 1.5 vs 9.6 ± 2, p < 0.001) after admission was significantly higher in the intervention group compared to the control group. The intervention group showed a significantly lower frequency of prolonged QTc interval 12 hours after admission (p = 0.003), as well as a significantly shorter hospital stay (p < 0.001).
SMOF Lipid infusion seemed to have improved GCS, the prolonged QTc interval, and shortened the length of hospital stay. Furthermore, there were no adverse effects related to its administration.
氯氮平是一种常用的抗精神病药物。各种病例报告记录了脂肪乳剂（ILE）给药在急性抗精神病药物中毒中的成功恢复。
本研究旨在评估 SMOF 脂质给药对急性氯氮平中毒结局的辅助治疗作用。
将 40 例急性氯氮平中毒患者随机分为两组。对照组仅接受标准支持治疗，而干预组则接受标准支持治疗加 SMOF 脂质 20%输注。所有患者均接受病史采集、全面临床检查和实验室检查。评估研究结果。
入院后 6 小时（13.1 ± 2.3 与 9.2 ± 2，p < 0.001）和 12 小时（14.3 ± 1.5 与 9.6 ± 2，p < 0.001）时，干预组的格拉斯哥昏迷量表（GCS）评分明显高于对照组。干预组入院后 12 小时 QTc 间期延长的频率明显较低（p = 0.003），住院时间明显缩短（p < 0.001）。
SMOF 脂质输注似乎改善了 GCS、延长的 QTc 间期，并缩短了住院时间。此外，其给药没有不良反应。
