多巴胺阻断可减弱肾上腺切除大鼠中盐水负荷引起的利钠作用。

Dopamine blockade attenuates the natriuresis of saline loading in the adrenalectomized rat.

作者信息

Jose P A, Holloway R R, Campbell T W, Eisner G M

机构信息

Department of Pediatrics, Georgetown University Medical Center, Washington, D.C.

出版信息

Nephron. 1988;48(1):54-7. doi: 10.1159/000184869.

DOI:10.1159/000184869

PMID:3340254

Abstract

Dopamine blockade with the dopamine-1/dopamine-2 antagonist cis-flupenthixol (CF) attenuates sodium excretion associated with saline loading in both innervated and denervated kidneys of the rat. Blockade of adrenal dopamine-2 receptors prevents the decrease in aldosterone secretion associated with saline loading and may also be responsible for the reduction in sodium excretion induced by CF. Therefore, to determine the role of adrenal dopamine-2 receptors in the attenuated natriuresis induced by CF, the effect of CF or vehicle treatment was examined in two groups of saline-loaded rats 80 (group I) and 120 min (group II) after adrenalectomy. In both groups, CF decreased glomerular filtration rate and sodium excretion after adrenalectomy. It is concluded that dopamine blockade attenuates the natriuresis associated with sodium loading by a direct effect in the kidney.

摘要

使用多巴胺 -1/多巴胺 -2拮抗剂顺式氟哌噻吨（CF）阻断多巴胺可减弱大鼠神经支配和去神经支配肾脏中与盐水负荷相关的钠排泄。阻断肾上腺多巴胺 -2受体会阻止与盐水负荷相关的醛固酮分泌减少，这也可能是CF诱导钠排泄减少的原因。因此，为了确定肾上腺多巴胺 -2受体在CF诱导的利钠作用减弱中的作用，在肾上腺切除术后80分钟（I组）和120分钟（II组）的两组盐水负荷大鼠中检查了CF或赋形剂治疗的效果。在两组中，肾上腺切除术后CF均降低了肾小球滤过率和钠排泄。得出的结论是，多巴胺阻断通过对肾脏的直接作用减弱了与钠负荷相关的利钠作用。