Chen Hsuan-Wei, Chiu Yi-Lin, Hsieh Tsai-Yuan, Chen Peng-Jen, Huang Tien-Yu, Lin Hsuan-Hwai, Shih Yu-Lueng, Lin Jung-Chun
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
J Inflamm Res. 2020 Dec 29;13:1207-1218. doi: 10.2147/JIR.S283768. eCollection 2020.
Vitamin D contributes to bone health and extra-skeletal effects. The mechanisms underlying vitamin D metabolism have not been extensively evaluated. The relationships between vitamin D and inflammatory cytokines are debated. Our objective was to investigate whether supplemental interferons are associated with longitudinal change of vitamin D status in humans.
A total of 48 patients with 24 or 48 weeks of pegylated interferon-α plus ribavirin therapy were examined for serum 25-hydroxyvitamin D (25[OH]D) level before treatment, at the end of treatment, and 24 weeks after treatment. In addition, we analyzed publicly available RNA sequencing data from accession GSE42697 and GSE7123 in the Gene Expression Omnibus.
The overall sustained virologic response (SVR) rate was 62.5%. There was no statistically significant association between baseline 25(OH)D concentrations and liver fibrosis. In patients with SVR, serum 25(OH)D increased markedly at end-of-treatment and decreased markedly by the end of the 24-week follow-up period. In the non-SVR group, this treatment-dependent change was lost. In gene expression analysis, the vitamin D biosynthesis process was activated in subjects with SVR, but not in patients without SVR. Furthermore, vitamin D receptor (VDR) signaling in peripheral blood mononuclear cells (PBMCs) was triggered in marked responders but not in poor responders.
In the aggregate, these data suggest that interferons have a regulatory influence on vitamin D status that can contribute to VDR signaling in PBMCs.
维生素D对骨骼健康和骨骼外效应有作用。维生素D代谢的潜在机制尚未得到广泛评估。维生素D与炎性细胞因子之间的关系存在争议。我们的目的是研究补充干扰素是否与人类维生素D状态的纵向变化相关。
共对48例接受24周或48周聚乙二醇化干扰素-α联合利巴韦林治疗的患者在治疗前、治疗结束时及治疗后24周检测血清25-羟基维生素D（25[OH]D）水平。此外，我们分析了基因表达综合数据库中登录号为GSE42697和GSE7123的公开可用RNA测序数据。
总体持续病毒学应答（SVR）率为62.5%。基线25(OH)D浓度与肝纤维化之间无统计学显著关联。在SVR患者中，血清25(OH)D在治疗结束时显著升高，在24周随访期结束时显著下降。在非SVR组中，这种依赖治疗的变化消失。在基因表达分析中，维生素D生物合成过程在SVR受试者中被激活，但在无SVR的患者中未被激活。此外，外周血单个核细胞（PBMC）中的维生素D受体（VDR）信号在明显应答者中被触发，但在低应答者中未被触发。
总体而言，这些数据表明干扰素对维生素D状态有调节作用，这可能有助于PBMC中的VDR信号传导。
