Alghad International Colleges for Applied Medical Sciences, Educational and Academic Affairs.
Taibah university, college of Applied Medical science, Medical Laboratory Science.
Afr Health Sci. 2020 Mar;20(1):392-396. doi: 10.4314/ahs.v20i1.45.
Sickle cell disease (SCD) is an inherited blood disorder that affects red blood cells. (SCD) is characterized by recurrent vaso-occlusive crisis (VOC).
This was a descriptive cross sectional study conducted through the period from July 2015 to July 2017 in which a total of seventy two blood specimens were collected in 'EDTA' and citrated vacutainers from Sudanese patients with SCD attending "Fath Elrhman Albasheer" Centre. Both sexes' with different ages were included. Among these samples 49 (68.1%) were in steady state while the remained 23 (31.9%) were in VOC. All samples were tested for coagulation profile.
There was increase in fibrinogen and D-dimer levels in most patients 67% and 71%, respectively. Significant increase in D-dimers was observed in patients with (VOC) compared with steady state (P. value = 0.006). Protein S was significantly increased in males in comparison with females P. value = 0.017. The results of prothrombin time (PT), international normalized ratio (INR) and thrombin time (TT) were within normal range.
Significant increase in levels of D-dimer during VOC indicating abnormal coagulation and fibrinolysis activation. Reduced levels of natural anticoagulants proteins C and S can be consider as predictive markers indicate hepatic dysfunction in patients with SCD.
镰状细胞病（SCD）是一种遗传性血液病，影响红细胞。（SCD）的特征是反复发作的血管阻塞性危象（VOC）。
这是一项描述性的横断面研究，于 2015 年 7 月至 2017 年 7 月期间进行，共从苏丹 SCD 患者在“Fath Elrhman Albasheer”中心采集了 72 份 EDTA 和枸橼酸盐真空采血管的血液标本。包括不同年龄和性别的患者。这些样本中，49 例（68.1%）处于稳定状态，其余 23 例（31.9%）处于 VOC 状态。所有样本均进行凝血谱检测。
大多数患者的纤维蛋白原和 D-二聚体水平分别增加了 67%和 71%。与稳定状态相比，患有（VOC）的患者 D-二聚体显著增加（P 值=0.006）。与女性相比，男性的蛋白 S 显著增加，P 值=0.017。凝血酶原时间（PT）、国际标准化比值（INR）和凝血酶时间（TT）结果均在正常范围内。
VOC 期间 D-二聚体水平显著升高，表明凝血和纤维蛋白溶解激活异常。天然抗凝蛋白 C 和 S 的水平降低可作为预测标志物，表明 SCD 患者存在肝损伤。
