垂体腺苷酸环化酶激活肽与促肾上腺皮质激素释放因子：两种功能相关肽在糖尿病性视网膜病变中的作用
PACAP and NAP: Effect of Two Functionally Related Peptides in Diabetic Retinopathy.
作者信息
D'Amico Agata Grazia, Maugeri Grazia, Musumeci Giuseppe, Reglodi Dora, D'Agata Velia
机构信息
Department of Drug Sciences, University of Catania, Catania, Italy.
Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Sciences, University of Catania, Catania, Italy.
出版信息
J Mol Neurosci. 2021 Aug;71(8):1525-1535. doi: 10.1007/s12031-020-01769-4. Epub 2021 Jan 5.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptide involved in physio-pathological processes of the eye. It exerts multiple effects directly through activation of its related receptors and indirectly through increases in the synthesis of activity-dependent neuroprotective protein (ADNP). To study the role of ADNP and protect against ADNP deficiencies, a small peptide called NAP was synthetized. It includes an eight amino acid active site sequence of ADNP. In this review, we summarize the knowledge regarding the neuroprotective function played by PACAP and NAP in retinal tissue and provide an overview of the correlation between PACAP and ADNP in the context of diabetic retinopathy.
垂体腺苷酸环化酶激活多肽（PACAP）是一种参与眼部生理病理过程的肽。它通过激活其相关受体直接发挥多种作用，并通过增加活性依赖性神经保护蛋白（ADNP）的合成间接发挥作用。为了研究ADNP的作用并预防ADNP缺乏，合成了一种名为NAP的小肽。它包含ADNP的一个八氨基酸活性位点序列。在本综述中，我们总结了关于PACAP和NAP在视网膜组织中发挥的神经保护功能的知识，并概述了糖尿病视网膜病变背景下PACAP与ADNP之间的相关性。
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