Mae Kenichiro, Tsuboi Ryoji, Irisawa Ryokichi, Sato Toshitsugu, Fukushima Noritoshi, Harada Kazutoshi
Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
Sato Dermatology Clinic, Tokyo, Japan.
J Dermatol. 2021 May;48(5):661-666. doi: 10.1111/1346-8138.15752. Epub 2021 Jan 6.
The present, retrospective, single-center study analyzed various factors associated with primary basal cell carcinoma (BCC) in the period before and after the introduction of dermoscopy (BD and AD, respectively). The demographic data of patients with primary BCC between 2001 and 2005 (BD: 84 patients, 90 cases) and 2011 and 2018 (AD: 297 patients, 320 cases) were analyzed. In the pigmented BCC-predominant cohort (94%), the proportion of smaller tumors as well as the total number of tumors significantly increased during AD (median tumor size, 10.0 mm in BD, 8.0 mm in AD; Mann-Whitney U-test, p = 0.011). BCC were excised with a significantly narrower margin during AD (median, 2.0 mm) than during BD (median, 3.0 mm; Mann-Whitney U-test, p < 0.001; odds ratio, 0.30; multivariate logistic regression analysis, p < 0.001); the incomplete excision rate was 1.9%, and the recurrence rate was 0%. The present study suggests that the introduction of dermoscopy might have aided in the early diagnosis of smaller BCC, especially in the face region, and determining the appropriate surgical margin. The smaller pigmented BCC can be excised with a narrower margin than stated in the guidelines (4 mm).
本回顾性单中心研究分析了在引入皮肤镜检查之前和之后(分别为BD和AD时期)与原发性基底细胞癌(BCC)相关的各种因素。分析了2001年至2005年(BD:84例患者,90例病例)和2011年至2018年(AD:297例患者,320例病例)原发性BCC患者的人口统计学数据。在以色素沉着性BCC为主的队列中(94%),AD期间较小肿瘤的比例以及肿瘤总数显著增加(肿瘤大小中位数,BD为10.0mm,AD为8.0mm;曼-惠特尼U检验,p = 0.011)。AD期间BCC切除的切缘明显比BD期间窄(中位数,2.0mm对3.0mm;曼-惠特尼U检验,p < 0.001;优势比,0.30;多因素逻辑回归分析,p < 0.001);不完全切除率为1.9%,复发率为0%。本研究表明,皮肤镜检查的引入可能有助于早期诊断较小的BCC,尤其是在面部区域,并有助于确定合适的手术切缘。较小的色素沉着性BCC可以用比指南规定(4mm)更窄的切缘切除。