Wang Weiwei, Xu Bolong, Pan Xueting, Zhang Junfeng, Liu Huiyu
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
State Key Laboratory of Engines, Tianjin University, Tianjin, 300350, P. R. China.
Angew Chem Int Ed Engl. 2021 Mar 29;60(14):7802-7808. doi: 10.1002/anie.202014895. Epub 2021 Feb 25.
Metal-organic frameworks (MOFs)-based yolk-shell nanostructures have drawn enormous attention recently due to their multifunctionality. However, the regulations of the size and morphology of yolk-shell nanostructures are still limited by the unclear formation mechanism. Herein, we first demonstrated a solvent-dependent adsorption-driven mechanism for synthesizing yolk-shelled MOFs-based nanostructures coated with mesoporous SiO shells (ZIF-8@mSiO ) with tunable size and morphology. The selective and competitive adsorption of methanol (CH OH) and water (H O) on ZIF-8 core were found to have decisive effects on inducing the morphology evolution of yolk-shell nanostructures. The obtained yolk-shelled ZIF-8@mSiO nanostructures show great promise in generating acoustic cavitation effect for sonodynamic cancer therapy in vitro. We believe that this work will not only help us to design novel MOFs-based yolk-shell nanostructures, but also promote the widespread application of MOFs materials.
基于金属有机框架（MOFs）的蛋黄壳纳米结构因其多功能性最近受到了极大关注。然而，蛋黄壳纳米结构的尺寸和形态调控仍受形成机制不明的限制。在此，我们首次证明了一种溶剂依赖的吸附驱动机制，用于合成包覆有介孔SiO壳（ZIF-8@mSiO）、尺寸和形态可调的基于蛋黄壳MOFs的纳米结构。发现甲醇（CH₃OH）和水（H₂O）在ZIF-8核上的选择性和竞争性吸附对诱导蛋黄壳纳米结构的形态演变具有决定性作用。所获得的蛋黄壳ZIF-8@mSiO纳米结构在体外声动力癌症治疗中产生声空化效应方面显示出巨大潜力。我们相信这项工作不仅将帮助我们设计新型的基于MOFs的蛋黄壳纳米结构，还将促进MOFs材料的广泛应用。
