用于研究真菌感染的造血细胞移植的鼠类模型。
Murine Models of Hematopoietic Cell Transplantation to Investigate Fungal Infections.
机构信息
Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Core Technology Facility, The University of Manchester, Manchester, UK.
出版信息
Methods Mol Biol. 2021;2260:207-214. doi: 10.1007/978-1-0716-1182-1_14.
PMID:33405040
Abstract
Animal models are fundamental to unravel the complex nature of fungal infections in the host context. Here, a versatile murine model of hematopoietic cell transplantation (HCT) is described. This model can be used to investigate the establishment and progression of fungal infections after HCT and to elucidate how different transplant variables affect the recovery of host immunity.
摘要
动物模型是揭示宿主背景下真菌感染复杂性质的基础。本文描述了一种灵活的造血细胞移植（HCT）小鼠模型。该模型可用于研究 HCT 后真菌感染的建立和进展，并阐明不同移植变量如何影响宿主免疫的恢复。
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