National Heart & Lung Institute, Imperial College London, London, UK.
Expert Rev Anti Infect Ther. 2012 Feb;10(2):149-51. doi: 10.1586/eri.11.169.
The increase in incidence of fungal infections is causing a considerable health burden worldwide. Despite recent advances in mucosal and systemic fungal diseases, a large gap exists in our knowledge of alterations to host homeostasis following fungal exposure and molecular mechanisms underlying fungal immune recognition, evasion and regulation. The EuroSciCon meeting on host-fungal interactions was expertly organized by Julian Naglik (King's College London, UK) and Neil Gow (University of Aberdeen, UK) and is aimed to be a premier forum in the UK for presentation of cutting-edge advances in relation to fungal pathogenicity and innate and adaptive immune responses. This article highlights principle topics that need to be better understood to provide improved means of diagnosis and optimization of therapies that would be instrumental in controlling fungal infections.
真菌感染发病率的增加在全球范围内造成了相当大的健康负担。尽管粘膜和系统性真菌感染方面最近取得了进展，但我们对真菌暴露后宿主内稳态的变化以及真菌免疫识别、逃避和调节的分子机制的了解仍存在很大差距。由 Julian Naglik（英国伦敦国王学院）和 Neil Gow（英国阿伯丁大学）精心组织的 EuroSciCon 宿主-真菌相互作用会议旨在成为英国在真菌致病性以及先天和适应性免疫反应方面的最前沿进展的首要论坛。本文重点介绍了需要更好地理解的主要主题，以提供改进的诊断手段和优化治疗方法，这对于控制真菌感染至关重要。
