免疫蛋白酶体抑制剂ONX-0914对小鼠海马体的长时程增强有影响。 - Suppr

Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus.

作者信息

Maltsev Alexander, Funikov Sergei, Burov Alexander, Spasskaya Daria, Ignatyuk Vasilina, Astakhova Tatjana, Lyupina Yulia, Deikin Alexey, Tutyaeva Vera, Bal Natalia, Karpov Vadim, Morozov Alexey

机构信息

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerovа 5A, 117485, Moscow, Russia.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov street 32, 119991, Moscow, Russia.

出版信息

J Neuroimmune Pharmacol. 2021 Mar;16(1):7-11. doi: 10.1007/s11481-020-09973-0. Epub 2021 Jan 6.

DOI:10.1007/s11481-020-09973-0

PMID:33405099

Abstract

摘要

相似文献

Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus.免疫蛋白酶体抑制剂ONX-0914对小鼠海马体的长时程增强有影响。

J Neuroimmune Pharmacol. 2021 Mar;16(1):7-11. doi: 10.1007/s11481-020-09973-0. Epub 2021 Jan 6.

ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in CoxsackievirusB3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage.ONX 0914 在 NMRI 小鼠柯萨奇病毒 B3 心肌炎中缺乏对心脏免疫蛋白酶体的选择性，并促进病毒介导的组织损伤。

Cells. 2020 Apr 28;9(5):1093. doi: 10.3390/cells9051093.

Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus.慢性给予非组成性蛋白酶体抑制剂调节小鼠海马长时程增强和谷氨酸信号相关基因表达。

Int J Mol Sci. 2023 May 3;24(9):8172. doi: 10.3390/ijms24098172.

Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation.免疫蛋白酶体抑制可预防肾移植中慢性抗体介导的移植物排斥反应。

Kidney Int. 2018 Mar;93(3):670-680. doi: 10.1016/j.kint.2017.09.023. Epub 2017 Dec 8.

Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines.γ干扰素诱导的免疫蛋白酶体亚基组装上调克服了人血液学细胞系中的硼替佐米耐药性。

J Hematol Oncol. 2014 Jan 13;7:7. doi: 10.1186/1756-8722-7-7.

The immunoproteasome inhibitor ONX-0914 regulates inflammation and expression of contraction associated proteins in myometrium.免疫蛋白酶体抑制剂 ONX-0914 调节肌层中的炎症和收缩相关蛋白的表达。

Eur J Immunol. 2018 Aug;48(8):1350-1363. doi: 10.1002/eji.201747458. Epub 2018 Jun 28.

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia.免疫蛋白酶体亚基 LMP2 和 LMP7 的共抑制可改善免疫性血小板减少症。

Front Immunol. 2021 Jan 20;11:603278. doi: 10.3389/fimmu.2020.603278. eCollection 2020.

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.免疫蛋白酶体抑制剂 ONX 0914 减轻 A/J 小鼠的病毒性心肌炎依赖于柯萨奇病毒 B3 感染中全身炎症反应的抑制。

Basic Res Cardiol. 2021 Feb 1;116(1):7. doi: 10.1007/s00395-021-00848-w.

Proteasome limits plasticity-related signaling to the nucleus in the hippocampus.蛋白酶体限制海马体中与可塑性相关的信号向细胞核的传递。

Neurosci Lett. 2018 Nov 20;687:31-36. doi: 10.1016/j.neulet.2018.09.017. Epub 2018 Sep 13.

Immunoproteasome Activity and Content Determine Hematopoietic Cell Sensitivity to ONX-0914 and to the Infection of Cells with Lentiviruses.免疫蛋白酶体活性和含量决定了造血细胞对 ONX-0914 和慢病毒感染细胞的敏感性。

Cells. 2021 May 12;10(5):1185. doi: 10.3390/cells10051185.

引用本文的文献

Int J Mol Sci. 2023 May 3;24(9):8172. doi: 10.3390/ijms24098172.

LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions.LMP2 缺乏会导致代谢异常、氧化应激、神经炎症、髓鞘丢失和神经行为功能障碍。

J Transl Med. 2023 Mar 28;21(1):226. doi: 10.1186/s12967-023-04071-0.

Amyloid Aβ Aggregates Say 'NO' to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na/Ca Exchanger.淀粉样蛋白 Aβ 聚集物通过激活应激诱导的磷酸酶 1 和线粒体 Na/Ca 交换器对海马体中的长时程增强说“不”。

Int J Mol Sci. 2022 Oct 6;23(19):11848. doi: 10.3390/ijms231911848.

Site-Specific Proteasome Inhibitors.靶向蛋白酶体抑制剂。

Biomolecules. 2021 Dec 31;12(1):54. doi: 10.3390/biom12010054.

A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes.基于细胞的平台，用于研究免疫蛋白酶体亚基β5i 的表达和含有β5i 的蛋白酶体的生物学特性。

Cells. 2021 Nov 5;10(11):3049. doi: 10.3390/cells10113049.

Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase.丝氨酸/苏氨酸磷酸酶在 LTP 中的作用：二选一还是二选二——蛋白合成抑制剂诱导早期相受损

Int J Mol Sci. 2021 May 4;22(9):4857. doi: 10.3390/ijms22094857.

本文引用的文献

LMP2 Inhibitors as a Potential Treatment for Alzheimer's Disease.LMP2 抑制剂作为治疗阿尔茨海默病的一种潜在疗法。

J Med Chem. 2020 Apr 9;63(7):3763-3783. doi: 10.1021/acs.jmedchem.0c00416. Epub 2020 Mar 30.

LTP suppression by protein synthesis inhibitors is NO-dependent.蛋白合成抑制剂抑制 LTP 是依赖于一氧化氮的。

Neuropharmacology. 2019 Mar 1;146:276-288. doi: 10.1016/j.neuropharm.2018.12.009. Epub 2018 Dec 9.

Biological consequences of structural and functional proteasome diversity.结构和功能蛋白酶体多样性的生物学后果。

Heliyon. 2018 Nov 2;4(10):e00894. doi: 10.1016/j.heliyon.2018.e00894. eCollection 2018 Oct.

Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70.重组 Hsp70 与蛋白酶体之间的相互作用：蛋白酶体活性的调节和 HSP70 的非泛素依赖性切割。

Cell Stress Chaperones. 2017 Sep;22(5):687-697. doi: 10.1007/s12192-017-0792-y. Epub 2017 Apr 26.

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function.一种调节神经元功能的哺乳动物神经系统特异性质膜蛋白酶体复合物。

Nat Struct Mol Biol. 2017 Apr;24(4):419-430. doi: 10.1038/nsmb.3389. Epub 2017 Mar 13.

Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.基于结构的人免疫蛋白酶体β1i 或 β5i 特异性抑制剂的设计。

J Med Chem. 2014 Jul 24;57(14):6197-209. doi: 10.1021/jm500716s. Epub 2014 Jul 15.

Reactive glia show increased immunoproteasome activity in Alzheimer's disease.阿尔茨海默病患者的反应性神经胶质细胞中免疫蛋白酶体活性增加。

Brain. 2013 May;136(Pt 5):1415-31. doi: 10.1093/brain/awt083. Epub 2013 Apr 19.

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.免疫蛋白酶体亚基LMP7的选择性抑制剂可阻断细胞因子的产生并减缓实验性关节炎的进展。

Nat Med. 2009 Jul;15(7):781-7. doi: 10.1038/nm.1978. Epub 2009 Jun 14.

J Neurochem. 2009 Jan;108(1):260-72. doi: 10.1111/j.1471-4159.2008.05762.x. Epub 2008 Nov 19.

A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP.蛋白质合成与蛋白酶体依赖性降解之间的平衡决定了长时程增强效应的维持。

Neuron. 2006 Oct 19;52(2):239-45. doi: 10.1016/j.neuron.2006.08.015.

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Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus.

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