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How the tissue factor-VIIa complex keeps two substrates in the loop.组织因子 - VIIa 复合物如何使两种底物保持在循环中。
J Thromb Haemost. 2021 Jan;19(1):52-54. doi: 10.1111/jth.15148.
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A serine loop in tissue factor mediates substrate selectivity by the tissue factor-factor VIIa complex.组织因子中的丝氨酸环通过组织因子-因子 VIIa 复合物来介导底物选择性。
J Thromb Haemost. 2021 Jan;19(1):75-84. doi: 10.1111/jth.15087. Epub 2020 Oct 1.
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Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property.在170环中修饰的凝血因子VIIa显示出增强的催化活性，但不改变类酶原特性。
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Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.组织因子与因子VIIa相互作用的结构-功能关系
Semin Thromb Hemost. 2015 Oct;41(7):682-90. doi: 10.1055/s-0035-1564044. Epub 2015 Sep 26.
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Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.与经抑肽酶突变体抑制的因子VIIa复合的细胞外组织因子的结构
J Mol Biol. 1999 Feb 5;285(5):2089-104. doi: 10.1006/jmbi.1998.2452.
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The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor.99和170环修饰的凝血因子VIIa突变体在无组织因子的情况下表现出增强的催化活性。
J Biol Chem. 2002 Dec 13;277(50):49027-35. doi: 10.1074/jbc.M203091200. Epub 2002 Oct 2.
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Factor VIIa residue Arg290 is required for efficient activation of the macromolecular substrate factor X.凝血因子VIIa的精氨酸290残基是有效激活大分子底物凝血因子X所必需的。
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Macromolecular substrate affinity for the tissue factor-factor VIIa complex is independent of scissile bond docking.组织因子 - 因子VIIa复合物对大分子底物的亲和力与可裂解键对接无关。
J Biol Chem. 1999 Aug 20;274(34):24171-5. doi: 10.1074/jbc.274.34.24171.
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Loop dynamics of the extracellular domain of human tissue factor and activation of factor VIIa.人组织因子细胞外结构域的环动力学与凝血因子VIIa的激活
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Dynamic character of the complex of human blood coagulation factor VIIa with the extracellular domain of human tissue factor: a normal mode analysis.人凝血因子VIIa与人体组织因子细胞外结构域复合物的动态特性：一种正常模式分析
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本文引用的文献

1
A serine loop in tissue factor mediates substrate selectivity by the tissue factor-factor VIIa complex.组织因子中的丝氨酸环通过组织因子-因子 VIIa 复合物来介导底物选择性。
J Thromb Haemost. 2021 Jan;19(1):75-84. doi: 10.1111/jth.15087. Epub 2020 Oct 1.
2
Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis.组织因子：止血的必要介质和血栓形成的触发因子。
Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):709-725. doi: 10.1161/ATVBAHA.117.309846. Epub 2018 Feb 8.
3
The Role of Putative Phosphatidylserine-Interactive Residues of Tissue Factor on Its Coagulant Activity at the Cell Surface.组织因子的假定磷脂酰丝氨酸相互作用残基在细胞表面对其凝血活性的作用
PLoS One. 2016 Jun 27;11(6):e0158377. doi: 10.1371/journal.pone.0158377. eCollection 2016.
4
Tissue factor residues that putatively interact with membrane phospholipids.可能与膜磷脂相互作用的组织因子残基。
PLoS One. 2014 Feb 6;9(2):e88675. doi: 10.1371/journal.pone.0088675. eCollection 2014.
5
Dynamical view of membrane binding and complex formation of human factor VIIa and tissue factor.人凝血因子 VIIa 和组织因子的膜结合和复合物形成的动力学观点。
J Thromb Haemost. 2010 May;8(5):1044-53. doi: 10.1111/j.1538-7836.2010.03826.x. Epub 2010 Feb 24.
6
Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation.将因子VIIa的活性位点提升至膜表面上方会降低其促凝血活性，但不会影响因子VII的自身激活。
J Biol Chem. 2006 Sep 8;281(36):26062-8. doi: 10.1074/jbc.M604915200. Epub 2006 Jul 11.
7
High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.对氨基苯甲脒和苯甲脒-VIIa/可溶性组织因子的高分辨率结构：192-193肽键的意外构象以及因子VIIa中Ca2+、Mg2+、Na+和Zn2+位点的定位
J Biol Chem. 2006 Aug 25;281(34):24873-88. doi: 10.1074/jbc.M509971200. Epub 2006 Jun 6.
8
The tissue factor region that interacts with factor Xa in the activation of factor VII.在因子VII激活过程中与因子Xa相互作用的组织因子区域。
Biochemistry. 2001 Jan 23;40(3):675-82. doi: 10.1021/bi002013v.
9
The tissue factor region that interacts with substrates factor IX and Factor X.与底物因子IX和因子X相互作用的组织因子区域。
Biochemistry. 2000 Jun 27;39(25):7380-7. doi: 10.1021/bi000182+.
10
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.与经抑肽酶突变体抑制的因子VIIa复合的细胞外组织因子的结构
J Mol Biol. 1999 Feb 5;285(5):2089-104. doi: 10.1006/jmbi.1998.2452.

How the tissue factor-VIIa complex keeps two substrates in the loop.

作者信息

Schulman Sol

机构信息

Divisions of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

出版信息

J Thromb Haemost. 2021 Jan;19(1):52-54. doi: 10.1111/jth.15148.

DOI:10.1111/jth.15148
PMID:33405385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117373/
Abstract
摘要