Fan Y L, Ye Q
Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2020 Dec 20;38(12):952-956. doi: 10.3760/cma.j.cn121094-20200305-00104.
Fibrotic lung diseases are a heterogeneous group of diffuse parenchymal lung diseases caused by various factors. Pulmonary fibrosis is one of the common pathological changes of advanced fibrotic lung diseases. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder with unknown etiology. IPF mainly affects the elderly that is considered as an aging related disease. Telomeres are specialized structures at the ends of chromosomes. Telomere shortening results in cellular senescence or apoptosis. Telomerase is a ribonucleoprotein complex that maintains telomere length and genome stability. The telomere shortening and mutations in telomere-related genes are associated with incidence and prognosis of pulmonary fibrosis. Here, a concise review of telomere and telomerase-related genomic markers in IPF and other fibrotic lung diseases is written.
纤维化性肺疾病是由多种因素引起的一组异质性弥漫性实质性肺疾病。肺纤维化是晚期纤维化性肺疾病的常见病理变化之一。特发性肺纤维化（IPF）是一种病因不明的慢性进行性纤维化性肺部疾病。IPF主要影响老年人，被认为是一种与衰老相关的疾病。端粒是染色体末端的特殊结构。端粒缩短会导致细胞衰老或凋亡。端粒酶是一种核糖核蛋白复合物，可维持端粒长度和基因组稳定性。端粒缩短和端粒相关基因的突变与肺纤维化的发生和预后相关。在此，撰写了一篇关于IPF和其他纤维化性肺疾病中端粒和端粒酶相关基因组标志物的简要综述。
