College of Nursing, 34996Pusan National University, Gyeongsangnam-do, Republic of Korea.
Elderly Frailty Research Center, Department of Family Medicine, College of Medicine, 26723Kyung Hee University, Seoul, Republic of Korea.
Biol Res Nurs. 2021 Jul;23(3):464-470. doi: 10.1177/1099800420983896. Epub 2021 Jan 7.
Epigenetic age acceleration has been studied as a promising biomarker of age-related conditions, including cognitive aging. This pilot study aims to explore potential cognitive aging-related biomarkers by investigating the relationship of epigenetic age acceleration and cognitive function and by examining the epigenetic age acceleration differences between successful cognitive aging (SCA) and normal cognitive aging (NCA) among Korean community-dwelling older adults (CDOAs).
We used data and blood samples of Korean CDOAs from the Korean Frailty and Aging Cohort Study. The participants were classified into two groups, SCA (above the 50th percentile in all domains of cognitive function) and NCA. The genome-wide DNA methylation profiling array using Illumina Infinium MethylationEPIC BeadChip was used to calculate the following: the DNA methylation age, universal epigenetic age acceleration, intrinsic epigenetic age acceleration (IEAA), and extrinsic epigenetic age acceleration (EEAA). We also used Pearson correlation analysis and independent -tests to analyze the data.
Universal age acceleration correlated with the Frontal Assessment Battery test results ( = -0.42, = 0.025); the EEAA correlated with the Word List Recognition test results ( = -0.41, = 0.027). There was a significant difference between SCA and NCA groups in IEAA ( = 0.041, Cohen's = 0.82) and EEAA ( = 0.042, Cohen's = 0.78).
Epigenetic age acceleration can be used as a biomarker for early detection of cognitive decline in Korean community-dwelling older adults. Large longitudinal studies are warranted.
表观遗传年龄加速已被研究作为一种有前途的生物标志物，用于预测与年龄相关的疾病，包括认知老化。本研究旨在通过探讨表观遗传年龄加速与认知功能的关系，并通过检查韩国社区居住老年人（CDOAs）中成功认知老化（SCA）和正常认知老化（NCA）之间的表观遗传年龄加速差异，探索潜在的认知老化相关生物标志物。
我们使用了来自韩国衰弱和老龄化队列研究的韩国 CDOAs 的数据和血液样本。参与者被分为 SCA（所有认知功能领域均高于第 50 个百分位数）和 NCA 两组。使用 Illumina Infinium MethylationEPIC BeadChip 进行全基因组 DNA 甲基化谱分析，以计算以下内容：DNA 甲基化年龄、通用表观遗传年龄加速、内在表观遗传年龄加速（IEAA）和外在表观遗传年龄加速（EEAA）。我们还使用 Pearson 相关分析和独立 t 检验来分析数据。
通用年龄加速与额叶评估电池测试结果相关（ = -0.42， = 0.025）；EEAA 与单词列表识别测试结果相关（ = -0.41， = 0.027）。SCA 和 NCA 组在 IEAA（ = 0.041，Cohen's = 0.82）和 EEAA（ = 0.042，Cohen's = 0.78）方面存在显著差异。
表观遗传年龄加速可作为韩国社区居住老年人认知能力下降早期检测的生物标志物。需要进行大规模的纵向研究。
