is a prognostic biomarker remodeling the tumor microenvironment in -driven lung adenocarcinoma.

To comprehensively analyze the expression profiles of ubiquitin-related genes (URGs) and determine potential biomarkers in -driven lung adenocarcinoma (LUAD). Differential expression analyses were performed between -wild and -mutant LUAD samples from The Cancer Genome Atlas database, and 34 URGs were screened out. ESTIMATE and CIBERSORT methods were used to calculate the ratio of immune and stromal components. was positively correlated with abundances of M2 macrophages and resting mast cells and negatively correlated with follicular helper T-cell abundances in -driven LUAD.  was a potential prognosis-associated indicator for tumor microenvironment modulation and played a key role in TME-specific AS landscapes alterations in -driven LUAD.