是一种预后生物标志物，重塑 - 驱动的肺腺癌中的肿瘤微环境。
is a prognostic biomarker remodeling the tumor microenvironment in -driven lung adenocarcinoma.
机构信息
Institute of Oncology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.
Department of Respiratory Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
出版信息
Future Oncol. 2021 Feb;17(5):565-579. doi: 10.2217/fon-2020-0645. Epub 2021 Jan 7.
To comprehensively analyze the expression profiles of ubiquitin-related genes (URGs) and determine potential biomarkers in -driven lung adenocarcinoma (LUAD). Differential expression analyses were performed between -wild and -mutant LUAD samples from The Cancer Genome Atlas database, and 34 URGs were screened out. ESTIMATE and CIBERSORT methods were used to calculate the ratio of immune and stromal components. was positively correlated with abundances of M2 macrophages and resting mast cells and negatively correlated with follicular helper T-cell abundances in -driven LUAD. was a potential prognosis-associated indicator for tumor microenvironment modulation and played a key role in TME-specific AS landscapes alterations in -driven LUAD.
为了全面分析泛素相关基因（URGs）的表达谱，并确定 - 驱动的肺腺癌（LUAD）中的潜在生物标志物。对来自癌症基因组图谱（TCGA）数据库的 - 野生型和 - 突变型 LUAD 样本进行差异表达分析，筛选出 34 个 URGs。使用 ESTIMATE 和 CIBERSORT 方法计算免疫和基质成分的比例。 在 - 驱动的 LUAD 中，与 M2 巨噬细胞和静止肥大细胞的丰度呈正相关，与滤泡辅助 T 细胞的丰度呈负相关。 是一个潜在的与肿瘤微环境调节相关的预后指标，在 - 驱动的 LUAD 的 TME 特异性 AS 景观改变中发挥关键作用。
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