Department of Radiology, The Third Affiliated Hospital of Guangxi Medical University, No. 13, Dancun Road, Nanning, 530031, China.
Department of Ultrasound, The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, China.
BMC Med Imaging. 2021 Jan 6;21(1):8. doi: 10.1186/s12880-020-00539-3.
To evaluate different stages of liver fibrosis in cynomolgus monkeys by comparing magnetic resonance-perfusion weighted imaging (MR-PWI) quantitative and semi-quantitative parameters, and confirm the best detection indicators for diagnosis of liver fibrosis.
A liver fibrosis model of different stages (S0-S4) was established in cynomolgus monkeys. The changes in MR-PWI quantitative and semi-quantitative parameters with the progression of liver fibrosis were investigated.
MR-PWI quantitative parameters gradually decreased with the progression of liver fibrosis. Hepatic arterial perfusion index (HPI) was found to increase with the progression of liver fibrosis and significant differences of HPI between each group were observed. There was a highly positive correlation between HPI and the stages of liver fibrosis. Receiver operating characteristic (ROC) curve analysis showed that HPI had the highest efficacy of the MR-PWI quantitative parameters for the diagnosis of liver fibrosis. The MR-PW semi-quantitative parameters gradually reduced with the progression of liver fibrosis, and the differences were statistically significant between stages S3-S4 and S0-S2. Time to peak (TPP) gradually extended and showed a positive correlation with the stages of liver fibrosis. TTP had the highest efficacy of the semi-quantitative parameters for diagnosis of liver fibrosis.
Both the MR-PWI quantitative and semi-quantitative parameters of the liver fibrosis model in cynomolgus monkeys varied at different stages of liver fibrosis, and HPI and TTP were the best detection indices for quantitative and semi-quantitative evaluation of liver fibrosis, respectively.
通过比较磁共振灌注加权成像（MR-PWI）定量和半定量参数，评估食蟹猴不同阶段的肝纤维化，并确定最佳检测指标用于诊断肝纤维化。
建立食蟹猴不同阶段（S0-S4）的肝纤维化模型，研究 MR-PWI 定量和半定量参数随肝纤维化进展的变化。
MR-PWI 定量参数随肝纤维化的进展逐渐降低。肝动脉灌注指数（HPI）随肝纤维化的进展而升高，各组之间 HPI 差异有统计学意义。HPI 与肝纤维化分期呈高度正相关。受试者工作特征（ROC）曲线分析显示，HPI 对肝纤维化的诊断具有最高的 MR-PWI 定量参数效能。MR-PW 半定量参数随肝纤维化的进展逐渐降低，分期 S3-S4 与 S0-S2 之间差异有统计学意义。达峰时间（TPP）逐渐延长，与肝纤维化分期呈正相关。TPP 对半定量参数诊断肝纤维化的效能最高。
食蟹猴肝纤维化模型的 MR-PWI 定量和半定量参数在肝纤维化的不同阶段均有变化，HPI 和 TPP 分别是定量和半定量评估肝纤维化的最佳检测指标。
