Liu Pei, Liang Wan-Li, Huang Rui-Ting, Chen Xin-Xing, Zou De-Hua, Kurihara Hiroshi, Li Yi-Fang, Xu You-Hua, Ouyang Shu-Hua, He Rong-Rong
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Front Pharmacol. 2024 Jul 23;15:1399598. doi: 10.3389/fphar.2024.1399598. eCollection 2024.
The liver, a complex parenchymal organ, possesses a distinctive microcirculatory system crucial for its physiological functions. An intricate interplay exists between hepatic microcirculatory disturbance and the manifestation of pathological features in diverse liver diseases. This review updates the main characteristics of hepatic microcirculatory disturbance, including hepatic sinusoidal capillarization, narrowing of sinusoidal space, portal hypertension, and pathological angiogenesis, as well as their formation mechanisms. It also summarized the detection methods for hepatic microcirculation. Simultaneously, we have also reviewed the characteristics of microcirculatory disturbance in diverse liver diseases such as acute liver failure, hepatic ischemia-reperfusion injury, viral hepatitis, non-alcoholic fatty liver disease, hepatic fibrosis, hepatic cirrhosis, and hepatocellular carcinoma. Finally, this review also summarizes the advancement in hepatic microcirculation attributed to traditional Chinese medicine (TCM) and its active metabolites, providing novel insights into the application of TCM in treating liver diseases.
肝脏是一个复杂的实质性器官，拥有一个对其生理功能至关重要的独特微循环系统。肝微循环障碍与各种肝脏疾病病理特征的表现之间存在着复杂的相互作用。本综述更新了肝微循环障碍的主要特征，包括肝血窦毛细血管化、窦状隙狭窄、门静脉高压和病理性血管生成，以及它们的形成机制。还总结了肝微循环的检测方法。同时，我们还综述了各种肝脏疾病如急性肝衰竭、肝缺血再灌注损伤、病毒性肝炎、非酒精性脂肪性肝病、肝纤维化、肝硬化和肝细胞癌的微循环障碍特征。最后，本综述还总结了中药及其活性代谢产物在肝微循环方面的进展，为中药在肝病治疗中的应用提供了新的见解。
