婴儿绞痛与睡眠问题及后续发育、情绪和行为问题的关系：一项纵向研究。
Association between colic and sleep problems in infancy and subsequent development, emotional and behavioral problems: a longitudinal study.
机构信息
Department of Nursing and Health promotion,Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.
Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway.
出版信息
BMC Pediatr. 2021 Jan 7;21(1):23. doi: 10.1186/s12887-020-02483-1.
BACKGROUND
Sleep and colic problems in infancy have been linked to adverse health outcome, but there is limited knowledge of the association between sleep and colic problems in infancy and subsequent development, emotional and behavior problems in young children. The aim of the present study was to examine whether there is an associations between infants' crying and sleep problems at 6 months and behavioral and development problems at 18 months, 3 and 5 years.
METHODS
This study is based on the Norwegian Mother, Father and Child Cohort Study (MoBa), conducted at the Norwegian Institute of Public Health from June 1999 to December 2008. A total of 86,724 children were included. Colic and sleep (sleep duration, nocturnal awakenings and easy to put to bed) was assessed by mother-reports. Z-scores were used to assess differences between groups of children (e.g. having colic or not, having a sleep problem or not). Emotional and behavioral problems were measured with items from the Child Behavior Checklist. Development problems were measured with items from The Ages and Stages Questionnaire.
RESULTS
Infants with colic scored significantly lower on development at 5 years (B=-0.10, CI [- 0.14 to - 0.06]) and higher on internalizing problems both at 3 years (B=0.15. CI [0.11 to 0.18]) and 5 years (B=0.17. CI [0.12 to 0.21]) than the reference population. Children who awoke frequently and were more difficult to put to bed at 6 months scored significantly lower on development at 18 months and 3 and 5 years, and higher on internalizing behavior problems at 3 and 5 years (B=0.18 and B=0.16). Children with shorter sleep duration at 6 months had more internalizing behavior problems at 3 years (B=0.14. CI [0.07 to 0.21]) and 5 years (B=0.15. CI [0.05 to 0.25]) than the reference population.
CONCLUSIONS
Colic and sleep problems early in life should be taken into account as risk factors for development and behavioral problems within the first 5 years of a child's life.
背景
婴儿期的睡眠和绞痛问题与不良健康结果有关，但对于婴儿期的睡眠和绞痛问题与幼儿期以后的发育、情绪和行为问题之间的关联，我们的了解有限。本研究旨在探讨婴儿在 6 个月时的哭泣和睡眠问题与 18 个月、3 岁和 5 岁时的行为和发育问题之间是否存在关联。
方法
本研究基于挪威母婴儿童队列研究（MoBa），该研究于 1999 年 6 月至 2008 年 12 月在挪威公共卫生研究所进行。共有 86724 名儿童被纳入研究。绞痛和睡眠（睡眠时间、夜间觉醒和入睡难易程度）由母亲报告评估。Z 分数用于评估不同组儿童之间的差异（例如，是否患有绞痛、是否存在睡眠问题等）。情绪和行为问题采用儿童行为检查表中的项目进行测量。发育问题采用年龄与阶段问卷中的项目进行测量。
结果
患有绞痛的婴儿在 5 岁时的发育得分显著较低（B=-0.10，CI [-0.14 至 -0.06]），在 3 岁（B=0.15，CI [0.11 至 0.18]）和 5 岁（B=0.17，CI [0.12 至 0.21]）时的内化问题得分显著较高。6 个月时频繁醒来且入睡困难的儿童在 18 个月、3 岁和 5 岁时的发育得分显著较低，在 3 岁和 5 岁时的内化行为问题得分显著较高（B=0.18 和 B=0.16）。6 个月时睡眠时间较短的儿童在 3 岁（B=0.14，CI [0.07 至 0.21]）和 5 岁（B=0.15，CI [0.05 至 0.25]）时的内化行为问题得分显著高于参考人群。
结论
婴儿期的绞痛和睡眠问题应被视为儿童生命前 5 年发育和行为问题的风险因素。
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