Université de Nantes, Institut de Cancérologie de l'Ouest, Saint-Herblain, F-44805, France.
SATT Ouest Valorisation, Nantes, France.
Theranostics. 2021 Jan 1;11(4):1568-1593. doi: 10.7150/thno.50683. eCollection 2021.
Macrophages are specialized cells that control tissue homeostasis. They include non-resident and tissue-resident macrophage populations which are characterized by the expression of particular cell surface markers and the secretion of molecules with a wide range of biological functions. The differentiation and polarization of macrophages relies on specific growth factors and their receptors. Macrophage-colony stimulating factor (CSF-1) and interleukine-34 (IL-34), also known as "twin" cytokines, are part of this regluatory landscape. CSF-1 and IL-34 share a common receptor, the macrophage-colony stimulating factor receptor (CSF-1R), which is activated in a similar way by both factors and turns on identical signaling pathways. However, there is some discrete differential activation leading to specific activities. In this review, we disscuss recent progress in understanding of the role of the twin cytokines in macrophage differentiation, from their interaction with CSF-1R and the activation of signaling pathways, to their implication in macrophage polarization of non-resident and tissue-resident macrophages. A special focus on IL-34, its involvement in pathophsyiological contexts, and its potential as a theranostic target for macrophage therapy will be proposed.
巨噬细胞是一种专门的细胞，可控制组织稳态。它们包括非驻留和组织驻留巨噬细胞群体，其特征在于表达特定的细胞表面标记物和分泌具有广泛生物学功能的分子。巨噬细胞的分化和极化依赖于特定的生长因子及其受体。巨噬细胞集落刺激因子（CSF-1）和白细胞介素-34（IL-34），也称为“双生子”细胞因子，是这一调控景观的一部分。CSF-1 和 IL-34 共享一个共同的受体，即巨噬细胞集落刺激因子受体（CSF-1R），这两种因子以相似的方式激活该受体，并开启相同的信号通路。然而，存在一些离散的差异激活，导致特定的活性。在这篇综述中，我们讨论了近年来对双生子细胞因子在巨噬细胞分化中的作用的理解的最新进展，从它们与 CSF-1R 的相互作用和信号通路的激活，到它们在非驻留和组织驻留巨噬细胞的极化中的作用。特别关注 IL-34，及其在病理生理情况下的参与，以及作为巨噬细胞治疗的治疗靶点的潜力。
