Coombs'-negative spherocytic hemolytic anemia and severe necrotizing renal vasculitis.

Vasculitis may be complicated by either hypoproliferative or hemolytic anemias. We have described a patient with a Coombs'-negative spherocytic hemolytic anemia and severe necrotizing renal vasculitis, two disorders not having been previously linked. The disorders were temporally related and both responded to immunosuppressive therapy. The precise cause of the hemolytic anemia remains unknown.