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三尖瓣介入治疗的新型经皮选择:如何识别合适的临床候选者。

New Percutaneous Options for Tricuspid Intervention: How to Identify the Good Clinical Candidate.

作者信息

Laricchia Alessandra, Khokhar Arif A, Giannini Francesco

机构信息

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.

出版信息

Front Cardiovasc Med. 2020 Dec 21;7:583307. doi: 10.3389/fcvm.2020.583307. eCollection 2020.

DOI:10.3389/fcvm.2020.583307
PMID:33409292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7779547/
Abstract

The tricuspid valve has been neglected for a long time and severe tricuspid regurgitation (TR) was largely undertreated in the past due to a high operative risk. In the last years we observed the development of different less invasive percutaneous options to treat TR. Currently, percutaneous treatments are reserved for high-risk patients presenting with advanced stage disease by which time they are likely to derive a partial benefit at best. There is a limited evidence base, including no randomized trials, to guide the management strategy for severe TR. In the interim we feel that choosing the best device for the most appropriate clinical candidate and with an adequate timing (most probably an "earlier" timing) will be the key combination to improve early and late outcomes of percutaneous treatments.

摘要

三尖瓣长期以来一直被忽视,过去由于手术风险高,严重三尖瓣反流(TR)在很大程度上未得到充分治疗。在过去几年中,我们观察到了不同的微创经皮治疗TR的方法的发展。目前,经皮治疗仅适用于患有晚期疾病的高危患者,而到那时他们最多只能获得部分益处。目前指导严重TR管理策略的证据基础有限,包括没有随机试验。在此期间,我们认为为最合适的临床候选者选择最佳装置并在适当的时机(很可能是“更早”的时机)进行治疗,将是改善经皮治疗早期和晚期结果的关键组合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a1b/7779547/c9b14fef2c4a/fcvm-07-583307-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a1b/7779547/c9b14fef2c4a/fcvm-07-583307-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a1b/7779547/c9b14fef2c4a/fcvm-07-583307-g0001.jpg

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JACC Cardiovasc Interv. 2020 Mar 9;13(5):554-564. doi: 10.1016/j.jcin.2019.10.058. Epub 2020 Jan 15.
2
Compassionate Use of the PASCAL Transcatheter Valve Repair System for Severe Tricuspid Regurgitation: A Multicenter, Observational, First-in-Human Experience.经导管 PASCAL 瓣膜修复系统治疗重度三尖瓣反流的同情使用:多中心、观察性、首例人体经验。
JACC Cardiovasc Interv. 2019 Dec 23;12(24):2488-2495. doi: 10.1016/j.jcin.2019.09.046.
3
Transcatheter edge-to-edge repair for reduction of tricuspid regurgitation: 6-month outcomes of the TRILUMINATE single-arm study.
经导管缘对缘修复术减少三尖瓣反流:TRILUMINATE 单臂研究的 6 个月结果。
Lancet. 2019 Nov 30;394(10213):2002-2011. doi: 10.1016/S0140-6736(19)32600-5. Epub 2019 Nov 7.
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Transcatheter Versus Medical Treatment of Patients With Symptomatic Severe Tricuspid Regurgitation.经导管与药物治疗有症状的重度三尖瓣反流患者的效果比较。
J Am Coll Cardiol. 2019 Dec 17;74(24):2998-3008. doi: 10.1016/j.jacc.2019.09.028. Epub 2019 Sep 27.
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