Smith C, Butler J, Cobb C, State D
Harbor-UCLA Medical Center, Department of Surgery, Torrance 90509.
Surgery. 1988 Feb;103(2):178-83.
To evaluate the role of fine-needle aspiration (FNA) cytology in the diagnosis of primary breast cancer, we reviewed our experience over a recent 5-year period at Harbor-UCLA Medical Center. A total of 590 aspirates with subsequent follow-up were documented. One hundred thirty-three primary cancers were histologically proved. Of the 133 cancers, 91 (68%) were diagnosed as malignant by aspiration cytologic examination; another 22 (17%) were reported as suspicious. Of the cancers, 8 (6%) had a benign cytologic diagnosis and 12 (9%) had unsatisfactory smears. No cytologic tests positive for malignancy were found to be benign on histologic examination. With an absolute sensitivity of 75% and a specificity of 100%, we conclude that FNA cytologic examination is highly accurate in the diagnosis of breast cancer. With no false-positive studies, the finding of a clearly malignant cytologic condition obviates the need for biopsy before mastectomy.
为评估细针穿刺（FNA）细胞学检查在原发性乳腺癌诊断中的作用，我们回顾了近期5年内在哈伯-加州大学洛杉矶分校医学中心的经验。共记录了590例有后续随访的穿刺样本。经组织学证实有133例原发性癌症。在这133例癌症中，91例（68%）经穿刺细胞学检查诊断为恶性；另有22例（17%）报告为可疑。在这些癌症中，8例（6%）细胞学诊断为良性，12例（9%）涂片结果不满意。组织学检查未发现细胞学检查呈恶性阳性的病例为良性。绝对敏感性为75%，特异性为100%，我们得出结论，FNA细胞学检查在乳腺癌诊断中高度准确。由于没有假阳性研究结果，明确的恶性细胞学检查结果可避免在乳房切除术前行活检。
