Weifang Medical University, Weifang, China.
Department of Neonatology, Wulian People's Hospital, Rizhao, China.
Reprod Sci. 2021 Sep;28(9):2413-2421. doi: 10.1007/s43032-020-00387-0. Epub 2021 Jan 6.
This systematic analysis aimed to summarize the effects of Y chromosome microdeletions (YCMs) on pregnancy outcomes of assisted reproductive technology (ART). This retrospective controlled meta-analysis evaluated the effect of YCMs on pregnancy outcomes of ART. Full-text retrieval was conducted in the PubMed, CBM, Web of Science, CNKI, VIP, and WANFANG databases. The pregnancy outcomes included fertilization rate, good embryo rate, clinical pregnancy rate, early miscarriage rate, miscarriage rate, live birth rate, and baby boy rate. The quality of these studies was evaluated using the Newcastle-Ottawa scale. Statistical software Review Manager 5.3 and STATA 14.0 were used. Twelve high-quality studies were included in the analysis. Compared with that in the normal group, the fertilization rate in the YCMs group decreased significantly (odds ratio [OR] = 0.75, 95% confidence interval [CI] [0.63, 0.88], P = 0.0006). However, there was no significant difference (P > 0.05) between groups in the good embryo rate (OR = 0.88, 95% CI [0.72, 1.07]), clinical pregnancy rate (OR = 0.94, 95% CI [0.78, 1.11]), early miscarriage rate (OR = 1.70, 95% CI [0.93, 3.10]), miscarriage rate (OR = 1.3, 95% CI [0.93, 1.91]), live birth rate (OR = 0.90, 95% CI [0.74, 1.08]), and baby boy rate (OR = 1.15, 95% CI [0.85, 1.56]). YCMs are associated with a reduced fertilization rate of ART, but they do not decrease the good embryo rate, clinical pregnancy rate, early miscarriage rate, miscarriage rate, live birth rate, or baby boy rate.
本系统分析旨在总结 Y 染色体微缺失（YCMs）对辅助生殖技术（ART）妊娠结局的影响。这项回顾性对照荟萃分析评估了 YCMs 对 ART 妊娠结局的影响。在 PubMed、CBM、Web of Science、CNKI、VIP 和 WANFANG 数据库中进行了全文检索。妊娠结局包括受精率、优质胚胎率、临床妊娠率、早期流产率、流产率、活产率和男婴率。使用纽卡斯尔-渥太华量表评估这些研究的质量。使用统计软件 Review Manager 5.3 和 STATA 14.0 进行分析。分析纳入了 12 项高质量研究。与正常组相比，YCMs 组的受精率显著降低（比值比[OR] = 0.75，95%置信区间[CI] [0.63, 0.88]，P = 0.0006）。然而，两组之间的优质胚胎率（OR = 0.88，95% CI [0.72, 1.07]）、临床妊娠率（OR = 0.94，95% CI [0.78, 1.11]）、早期流产率（OR = 1.70，95% CI [0.93, 3.10]）、流产率（OR = 1.3，95% CI [0.93, 1.91]）、活产率（OR = 0.90，95% CI [0.74, 1.08]）和男婴率（OR = 1.15，95% CI [0.85, 1.56]）无显著差异（P > 0.05）。YCMs 与 ART 受精率降低相关，但不降低优质胚胎率、临床妊娠率、早期流产率、流产率、活产率或男婴率。
