Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA.
Center for Drug Delivery & Research, Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
Ther Deliv. 2021 Jan;12(1):77-103. doi: 10.4155/tde-2020-0096. Epub 2021 Jan 7.
Microneedle (MN)-based technologies are currently one of the most innovative approaches that are being extensively investigated for transdermal delivery of low molecular weight drugs, biotherapeutic agents and vaccines. Extensive research reports, describing the fabrication and applications of different types of MNs, can be readily found in the literature. Effective characterization tools to evaluate the quality and performance of the MNs as well as for determination of the dimensional and kinetic properties of the microchannels created in the skin, are an essential and critical part of MN-based research. This review paper provides a comprehensive account of all such tools and techniques.
基于微针（MN）的技术是目前最具创新性的方法之一，广泛用于透皮输送低分子量药物、生物治疗剂和疫苗。在文献中可以很容易地找到大量描述不同类型 MN 的制造和应用的研究报告。有效的特性评估工具对于评估 MN 的质量和性能以及确定在皮肤中创建的微通道的尺寸和动力学特性至关重要，是 MN 研究的重要组成部分。本文综述全面介绍了所有这些工具和技术。
