Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Rheumatology (Oxford). 2021 Mar 2;60(3):1042-1053. doi: 10.1093/rheumatology/keaa910.
OA is a complex and highly prevalent degenerative disease affecting the whole joint, in which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint destruction. ∼50-80% of OA patients develop synovitis. OA-associated risk factors contribute to joint instability and the release of cartilage matrix fragments, activating the synovium to release pro-inflammatory factors and catabolic enzymes in turn damaging the cartilage and creating a vicious circle. Currently, no cure is available for OA. Mesenchymal stromal cells (MSCs) have been tested in OA for their chondrogenic and anti-inflammatory properties. Interestingly, MSCs are most effective when administered during synovitis. This review focusses on the interplay between joint inflammation and the immunomodulation by MSCs in OA. We discuss the potential of MSCs to break the vicious circle of inflammation and describe current perspectives and challenges for clinical application of MSCs in treatment and prevention of OA, focussing on preventing post-traumatic OA.
骨关节炎是一种复杂且普遍的退行性关节疾病，影响整个关节，遗传易感性、性别、年龄、肥胖和创伤等因素导致关节破坏。∼50-80%的骨关节炎患者会出现滑膜炎。与骨关节炎相关的危险因素导致关节不稳定和软骨基质碎片的释放，从而激活滑膜释放促炎因子和分解代谢酶，进而破坏软骨并形成恶性循环。目前，骨关节炎尚无治愈方法。间充质基质细胞 (MSCs) 因其软骨生成和抗炎特性已在骨关节炎中进行了测试。有趣的是，当在滑膜炎期间给予 MSCs 时，其效果最佳。本综述重点介绍了关节炎症与 MSCs 免疫调节之间的相互作用。我们讨论了 MSCs 打破炎症恶性循环的潜力，并描述了 MSCs 在治疗和预防骨关节炎中的临床应用的当前观点和挑战，重点是预防创伤后骨关节炎。
