母体硒缺乏对甲基汞致畸性的影响。

Effect of maternal selenium deficiency on the teratogenicity of methylmercury.

作者信息

Nishikido N, Satoh Y, Naganuma A, Imura N

机构信息

Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Toxicol Lett. 1988 Feb;40(2):153-7. doi: 10.1016/0378-4274(88)90156-7.

DOI:10.1016/0378-4274(88)90156-7

PMID:3341056

Abstract

The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 mumol/kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and selenium-sufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestational period for an MMC-induced cleft palate.

摘要

在ICR品系缺硒和富硒小鼠中研究了甲基汞的致畸性。在妊娠第10、11或12天经口单次给予75 μmol/kg氯化甲基汞（MMC），缺硒和富硒小鼠发生腭裂的发生率相似。在第11天进行处理时，两组腭裂发生率均最高。这些结果表明，母体缺硒对MMC诱导腭裂的发生率或关键妊娠期没有影响。