铜绿假单胞菌对头孢地尔罗耐药性的演变：一位既往未使用过该抗生素患者的病例报告。
Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic.
机构信息
Center for Antimicrobial Resistance and Microbial Genomics, UTHealth McGovern School of Medicine, Houston, Texas, USA.
Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina-EPM, São Paulo-SP, Brazil.
出版信息
Clin Infect Dis. 2021 Dec 6;73(11):e4472-e4474. doi: 10.1093/cid/ciaa1909.
Abstract
We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.
摘要
我们报告了从一名没有头孢地尔暴露史的患者中分离出的铜绿假单胞菌亚群对头孢地尔产生耐药性的情况。全基因组测序鉴定出了先前与头孢地尔摄取相关的主要铁转运途径的突变。在使用铁载体头孢菌素治疗之前，应进行药敏试验。
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