Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
J Infect Dis. 2021 Apr 8;223(7):1145-1149. doi: 10.1093/infdis/jiab005.
Most patients with coronavirus disease 2019 (COVID-19) experience asymptomatic disease or mild symptoms, but some have critical symptoms requiring intensive care. It is important to determine how patients with asymptomatic or mild COVID-19 react to severe acute respiratory syndrome coronavirus 2 infection and suppress virus spread. Innate immunity is important for evasion from the first virus attack, and it may play an important role in the pathogenesis in these patients. We measured serum cytokine levels in 95 patients with COVID-19 during the infection's acute phase and report that significantly higher interleukin 12 and 2 levels were induced in patients with asymptomatic or mild disease than in those with moderate or severe disease, indicating the key roles of these cytokines in the pathogenesis of asymptomatic or mild COVID-19.
大多数 2019 冠状病毒病（COVID-19）患者无症状或症状轻微，但有些患者则出现需要重症监护的危急症状。了解无症状或轻症 COVID-19 患者对严重急性呼吸综合征冠状病毒 2 感染的反应并抑制病毒传播非常重要。先天免疫对于逃避首次病毒攻击很重要，它可能在这些患者的发病机制中发挥重要作用。我们在感染急性期测量了 95 例 COVID-19 患者的血清细胞因子水平，报告称无症状或轻症患者的白细胞介素 12 和 2 水平显著升高，而中症或重症患者则较低，这表明这些细胞因子在无症状或轻症 COVID-19 的发病机制中起关键作用。
