Barcelona Institute for Global Health (Isglobal), Hospital Clínic - University of Barcelona, Barcelona, Spain.
Expert Rev Anti Infect Ther. 2021 Dec;19(12):1489-1494. doi: 10.1080/14787210.2021.1873130. Epub 2021 Jan 11.
: Diagnosis of chronic Chagas disease relies on the agreement of two conventional serological tests based on distinct antigens. These require cold to preserve reagents and samples, and equipment and trained personnel to run them. Moreover, results turnaround may be delayed for several weeks risking a loss to follow-up of infected subjects, summoning major disadvantages to access diagnosis (and treatment) in many highly endemic areas.: Recent studies have shown the versatility of rapid diagnostic tests for the detection of chronic infections in referral centers and in field campaigns, with a performance equivalent to that of conventional tools. Remarkably, RDTs do not require cold storage and provide results within an hour. Additionally, they are easy-to-use and can work with a tiny volume of finger-pricked whole blood. Altogether, major advantages toward generalizing their use as an alternative to conventional tests.: Already in 2021, only a small percentage of -infected people are diagnosed and treated. The unsuitability of currently used diagnostics, and of the recommended algorithm, to the conditions found in many regions do not help to fill this gap. RDTs stand as a promising solution, even though geographical validation should precede their implementation.
: 慢性恰加斯病的诊断依赖于两种基于不同抗原的常规血清学检测的一致性。这些检测需要冷藏来保存试剂和样本，并且需要设备和经过培训的人员来运行它们。此外，结果可能需要数周的时间才能得出，这有可能导致感染患者的随访丢失，给许多高度流行地区的诊断（和治疗）带来了重大不便。: 最近的研究表明，快速诊断检测在转诊中心和实地运动中检测慢性感染的多功能性，其性能与传统工具相当。值得注意的是，RDT 不需要冷藏，并且可以在一个小时内提供结果。此外，它们易于使用，并且可以使用指尖的少量全血进行工作。总的来说，它们作为替代传统检测的一种方法具有很大的优势。: 尽管快速诊断检测有很大的优势，但在 2021 年，只有一小部分感染的人得到了诊断和治疗。目前使用的诊断方法和推荐的算法不适用于许多地区的情况，这无助于填补这一空白。RDT 是一个有前途的解决方案，尽管在实施之前应该进行地理验证。
