UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, Australia.
QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia.
Breast Cancer Res. 2021 Jan 7;23(1):6. doi: 10.1186/s13058-020-01384-6.
Invasive lobular carcinoma (ILC) is the most common of the breast cancer special types, accounting for up to 15% of all breast cancer cases. ILCs are noted for their lack of E-cadherin function, which underpins their characteristic discohesive growth pattern, with cells arranged in single file and dispersed throughout the stroma. Typically, tumours are luminal in molecular subtype, being oestrogen and progesterone receptor positive, and HER2 negative. Since last reviewing the lobular literature (McCart Reed et al., Breast Cancer Res 17:12, 2015), there has been a considerable increase in research output focused on this tumour type, including studies into the pathology and management of disease, a high-resolution definition of the genomic landscape of tumours as well as the evolution of several potential therapeutic avenues. There abounds a huge amount of new data, which we will review herein.
浸润性小叶癌（ILC）是最常见的乳腺癌特殊类型之一，占所有乳腺癌病例的 15%。ILC 的特点是缺乏 E-钙黏蛋白功能，这支撑了其特征性的分离生长模式，细胞呈单行排列并散布在基质中。通常，肿瘤在分子亚型上是腔型的，雌激素和孕激素受体阳性，HER2 阴性。自上次审查小叶文献（McCart Reed 等人，Breast Cancer Res 17:12, 2015）以来，针对这种肿瘤类型的研究产出显著增加，包括对疾病的病理学和管理的研究，对肿瘤基因组景观的高分辨率定义以及几个潜在治疗途径的演变。这里有大量的新数据，我们将在本文中进行综述。
