El-Habeeb Abeer A
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Bioinorg Chem Appl. 2020 Dec 18;2020:6678688. doi: 10.1155/2020/6678688. eCollection 2020.
In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses. The synthesized folate complexes were also subject to thermal analysis (TGA) to better examine their thermal degradation and kinetic properties. The folate complexes had high stability and were nonspontaneous. The Coats-Redfern and Horowitz-Metzger equations were used to determine thermodynamic parameters and describe the kinetic properties. These complexes were synthesized through the chemical interactions in neutralized media between the folic acid drug ligand (FAH) with GaCl, GeCl, and HfCl metal salts at 1 : 2 (metal : ligand) molar ratio. The conductance measurements have low values due to their nonelectrolytic behavior. The X-ray powder diffraction solid powder pattern revealed a semicrystalline nature. In vitro, we screened the synthesized folate chelates for antibacterial and antifungal activities. The inhibition of four bacterial and two fungi pathogens (, , , , , and ) was improved using a folic acid drug relative to the control drug.
在本研究中，我们描述了新型镓（III）、锗（IV）和铪（IV）叶酸配合物，包括它们的合成与分析。合成的叶酸配合物还进行了热分析（TGA），以更好地研究其热降解和动力学性质。叶酸配合物具有高稳定性且是非自发的。使用科茨 - 雷德芬（Coats-Redfern）方程和霍洛维茨 - 梅茨格（Horowitz-Metzger）方程来确定热力学参数并描述动力学性质。这些配合物是通过叶酸药物配体（FAH）与GaCl、GeCl和HfCl金属盐在1∶2（金属∶配体）摩尔比的中和介质中的化学相互作用合成的。由于其非电解质行为，电导率测量值较低。X射线粉末衍射固体粉末图谱显示出半结晶性质。在体外，我们筛选了合成的叶酸螯合物的抗菌和抗真菌活性。相对于对照药物，使用叶酸药物提高了对四种细菌和两种真菌病原体（，，，，，和）的抑制作用。
