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[撤回]去甲斑蝥素通过调节 YAP 通路逆转人非小细胞肺癌顺铂耐药并抑制上皮间质转化。

[Retracted] Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway.

机构信息

Department of Pain Medicine, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.

Cancer Research Institute, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.

出版信息

Oncol Rep. 2021 Jan;45(1):408. doi: 10.3892/or.2020.7830. Epub 2020 Nov 2.

Abstract

An interested reader drew to our attention that the western blots featured in Figs. 1B and 6C contained strikingly similar protein bands, and repeating patterns of bands, comparing across the lanes of the gels. Furthermore, an image representing the Myc‑YAP colony‑formation assay experiment in Fig. 2C was strikingly similar to the data shown for the Control colony‑formation assay experiment in Fig. 5B. The Editorial office subsequently investigated this matter further, and noted that the western blots shown in Fig. 6A and B likewise contained strikingly similar bands that were purportedly showing the results from different experiments. After having considered the various issues that have been brought to light with this paper, together with an appeal from the authors that a Corrigendum be published, the Editor of Oncology Reports has ruled that the article should be retracted from the publication on account of a lack of overall confidence in the presented data. Note that the authors were not in agreement that the errors reported and identified were sufficient to merit the retraction of the article. The Editor apologizes to the readership for any inconvenience caused. [the original article was published in Oncology Reports 40: 609-620, 2018; DOI: 10.3892/or.2018.6486].

摘要

一位感兴趣的读者提请我们注意,图 1B 和图 6C 中的蛋白质印迹显示出惊人相似的蛋白条带和条带重复模式,跨胶条进行比较。此外,图 2C 中代表 Myc-YAP 集落形成测定实验的图像与图 5B 中对照集落形成测定实验的数据惊人地相似。编辑部随后进一步调查了此事,并注意到图 6A 和图 6B 中所示的蛋白质印迹也包含惊人相似的条带,据称这些条带显示了来自不同实验的结果。在考虑了本文中提出的各种问题,以及作者呼吁发布更正后,肿瘤报告编辑决定因对所呈现数据缺乏整体信心而撤回该文章。请注意,作者并不认为所报告和确定的错误足以证明撤回该文章。编辑向读者表示歉意,给您带来了不便。[原始文章发表于肿瘤报告 40:609-620, 2018;DOI: 10.3892/or.2018.6486]。

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