Long Noncoding RNA Small Nucleolar RNA Host Gene 3 Mediates Prostate Cancer Migration, Invasion, and Epithelial-Mesenchymal Transition by Sponging miR-487a-3p to Regulate .

Long noncoding RNA small nucleolar RNA host gene 3 () is related to the proliferation and metastasis of cancer cells. This study aims to reveal the role of in prostate cancer (PCa), which may help prevent PCa metastasis. plasmid, siRNA, miR-487a-3p mimic, miR-487a-3p inhibitor, plasmid, and siRNA were transfected or cotransfected into LNCaP and PC-3 cells. The proliferation, migration, and invasion of PCa cells were measured by Cell Counting Kit-8, wound-healing, and transwell assays, respectively. The expressions of , miR-487a-3p, E-cadherin, N-cadherin, Snail, and in PCa tissues and cells were measured by quantitative reverse transcription polymerase chain reaction or Western blot. expression level was upregulated in PCa tissues and cells. overexpression and miR-487a-3p inhibitor promoted cell viability, migration, invasion, and N-cadherin and Snail levels, and inhibited E-cadherin level in LNCaP cells, while silencing and miR-487a-3p mimic had the opposite effects on PC-3 cells. The inhibitory effect of miR-487a-3p mimic on the migration, invasion, and epithelial-mesenchymal transition (EMT) of LNCaP cells was inversed by both and plasmids. Similarly, the function of miR-487a-3p inhibitor in PC-3 cells was also inversed by siRNA and siRNA. mediates PCa migration, invasion, and EMT by sponging miR-487a-3p to regulate . The Clinical Trial Registration number: Y20180831.