Reid D M, Shulman N R
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Ann Intern Med. 1988 Feb;108(2):206-8. doi: 10.7326/0003-4819-108-2-206.
Three patients had recurrent episodes of thrombocytopenia that resembled drug purpura, but the drug history in each case did not support the diagnosis. Although the patients specifically denied taking quinidine, serologic testing with this drug was done because the patients had access to it, and it is the commonest cause of drug purpura. Highly specific quinidine-dependent antiplatelet antibodies were found in the sera of all three patients. After being informed of the laboratory findings, the patients have had no recurrences of purpura. Serologic tests for quinidine- or quinine-dependent antibodies can help elucidate some obscure cases of purpura that may be self-induced.
三名患者出现了类似药物性紫癜的血小板减少复发情况，但每例患者的用药史均不支持该诊断。尽管患者明确否认服用过奎尼丁，但由于患者有可能接触到该药物，且它是药物性紫癜最常见的病因，因此对其进行了血清学检测。在所有三名患者的血清中均发现了高度特异性的奎尼丁依赖性抗血小板抗体。在告知患者实验室检查结果后，紫癜未再复发。针对奎尼丁或奎宁依赖性抗体的血清学检测有助于阐明一些可能是自身诱发的紫癜疑难病例。
