From the Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai.
Spandan Superspeciality Clinic, Aurangabad, India.
Clin Nucl Med. 2021 Jul 1;46(7):e349-e352. doi: 10.1097/RLU.0000000000003492.
A 43-year-old man diagnosed with fibrous dysplasia with McCune-Albright syndrome was subjected to 18F-fluoride bone scan and 68Ga-PSMA-HBED-CC PET/CT as per the institution protocol. 18F-bone scan revealed extensive involvement of axial and appendicular skeleton confirming polyostotic fibrous dysplasia. 68Ga-PSMA PET/CT showed increased tracer uptake in corresponding lesions of fibrous dysplasia. PSMA uptake in fibrous dysplasia lesions has been rarely described with literature evidence being limited to anecdotal case reports. Nevertheless, due to increasing use of PSMA PET/CT, one should be aware of this false-positive finding to avoid misinterpretation of the scans.
一位 43 岁男性，被诊断为纤维结构不良伴 McCune-Albright 综合征，根据医院的方案进行了 18F-氟化物骨扫描和 68Ga-PSMA-HBED-CC PET/CT 检查。18F-骨扫描显示广泛累及轴骨和附肢骨骼，证实为多骨纤维结构不良。68Ga-PSMA PET/CT 显示纤维结构不良病变的示踪剂摄取增加。纤维结构不良病变中 PSMA 摄取的描述很少见，文献证据仅限于偶发的病例报告。然而，由于 PSMA PET/CT 的使用越来越多，人们应该意识到这一假阳性发现，以避免对扫描的错误解读。
