Fitness Cost of Antibiotic Resistance in : A Systematic Review.

Recent reports have shown the potential of for acquiring resistance to last-resort antibiotics. However, most antibiotic resistance mechanisms were associated with a fitness cost that was typically observed as a reduced bacterial growth rate. This systematic review aimed to address the fitness cost of antibiotic resistance in that emerged by mutations. A systematic review was conducted after searching in two databases (PubMed and Scopus) using specific keywords. We included peer-reviewed articles published only in English. All studies describing the fitness cost associated with antibiotic resistance in were selected. For each article, the results of fitness testing, minimum inhibition concentrations of mutants, the position of mutation, and the appearance of compensatory mutations were recorded. At all, 35 articles were recorded in the final analysis examining the fitness cost associated with antibiotic resistance in that conferred by mutations. Analysis of the data showed that 26 studies reported that the emergence of antibiotic resistance was frequently associated with a fitness cost. This review summarized that the antibiotic resistance selection caused in the majority of cases a substantial fitness cost. Further experiments revealed that these mutations affected bacterial virulence and the ability to establish a successful infection.