一个神经元的大跨越，miRNAs 的两个小步骤。

One Big Step to a Neuron, Two Small Steps for miRNAs.

机构信息

Neural Aging Laboratory, Institute of Molecular Biology, CMBI, Leopold-Franzens-University Innsbruck, Austria; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.

Neural Aging Laboratory, Institute of Molecular Biology, CMBI, Leopold-Franzens-University Innsbruck, Austria.

出版信息

Cell Stem Cell. 2021 Jan 7;28(1):1-2. doi: 10.1016/j.stem.2020.12.007.

DOI:10.1016/j.stem.2020.12.007

PMID:33417865

Abstract

Direct cell fate conversion of human somatic cells into induced neurons (iNs) is often regarded as a highly concerted one-step process. In this issue of Cell Stem Cell, Cates et al. (2021) dissect the iN conversion trajectory into two largely independent steps and identify key players at each stage.

摘要

直接将人体成体细胞转化为诱导性神经元（iNs）通常被认为是一个高度协调的一步过程。在本期的《Cell Stem Cell》杂志上，Cates 等人（2021）将 iN 转化轨迹细分为两个基本独立的步骤，并确定了每个阶段的关键因素。