Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States.
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States.
J Neuroradiol. 2022 Jan;49(1):53-58. doi: 10.1016/j.neurad.2020.12.004. Epub 2021 Jan 5.
The purpose of this study was to assess for any differences in brain maturation, structure and morphometry in fetuses exposed to opioids in utero, compared to non-opioid exposed fetuses on fetal MRI.
We performed a prospective study in pregnant women using opioids and healthy pregnant women without prenatal opioid use. We evaluated brain maturation, structure, and morphometry on second or third trimester fetal MRI and assessed group differences.
28 pregnant women were enrolled, 12 with opioid exposure (average gestational age 33.67, range 28-39 w), 9 of whom also smoked, and 16 without opioid exposure (average gestational age 32.53, range 27-38 w). There was a significant difference in the anteroposterior diameter of the fetal cerebellar vermis in the opioid exposed fetuses compared to non-opioid exposed fetuses (p = 0.004). There were no significant differences in brain biparietal diameter, fronto-occipital diameter, transverse cerebellar diameter and anteroposterior dimension of the pons in opioid exposed fetuses compared to non-opioid exposed fetuses. There were no abnormalities in brain maturation and no major brain structural abnormalities in the opioid exposed fetuses.
Smaller fetal anteroposterior cerebellar vermian dimension was associated with in utero opioid exposure. There were no abnormalities in brain maturation or major structural abnormalities in fetuses exposed to opioids.
本研究旨在评估胎儿在宫内暴露于阿片类药物与非阿片类药物暴露胎儿之间在大脑成熟度、结构和形态测量方面的差异，方法：我们对使用阿片类药物的孕妇和未使用产前阿片类药物的健康孕妇进行了前瞻性研究。我们在胎儿 MRI 上评估了胎儿在第二或第三个三个月的大脑成熟度、结构和形态测量，并评估了组间差异。结果：共纳入 28 名孕妇，12 名暴露于阿片类药物（平均孕龄 33.67，范围 28-39 周），其中 9 名还吸烟，16 名未暴露于阿片类药物（平均孕龄 32.53，范围 27-38 周）。与非阿片类药物暴露胎儿相比，阿片类药物暴露胎儿的小脑蚓部前后径有显著差异（p=0.004）。与非阿片类药物暴露胎儿相比，阿片类药物暴露胎儿的大脑双顶径、额枕径、小脑横径和桥前前后径无显著差异。阿片类药物暴露胎儿的大脑成熟无异常，也无主要大脑结构异常。结论：小脑蚓部前后径较小与胎儿宫内阿片类药物暴露有关。阿片类药物暴露胎儿的大脑成熟或主要结构异常。
